Time today symptoms and conditions

OMG I am so glad I found this side. I have just started taking Yasmin.

Previously I was on Mercilon and found that I got very nauseous a few days before my period was due (this happened a week ago on Friday) so I asked the doctor to change my pill and he prescribed Yasmin. I have IBS and last Wednesday I had a several attack (I was on my period as well). I then started taking Yasmin the next day. By Saturday I had to spend the day in bed as I felt so sick. I actually thought I was going to be sick. There is a bug going round work so thought it might of had something to do with that or my IBS. IT started to clear by the beginning of this week, but even now my stomach feels like someone has kicked me, I just cant eat (the thought just turns my stomach) and I feel sick ALL of the time. Today I realised that this is most likely due to the Yasmin. I am going back on Mercilon as of next month. I decided I would rather put up with one day of feeling sick than all the time! The doctor and the pharmastic told me to continue taking Yasmin till my period but I just cant do that. I am not covered this month anyway because I changed mid way through my period so I might as well not take it and be careful for a month.

My sister takes Yasmin and has no problems at ill but its the worst one I have ever taken. I had problems with Dianette as well but my body cant take the high Oestrogen levels. I think it is weird how a pill can work for one woman and not the next when effectively they do the same thing!

Sorry, I can't just walk away.

When you find patents or patent applications for certain purposes, then you know that your ideas are well founded. There are several patents for using an anti-malaria drug for asthma. I would bet that somebody had that idea all the way back to the 1960's. So it is very possibly no coincidence at all that a chloroquinoline or other quinoline ring would be part of montelukast's chemical structure.

Here is one of the patents.

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It is well known that quinoline rings can be toxic to some people even very rapidly. As in this very extreme example.
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PEDIATRICS Vol. 27 No. 1 January 1961, pp. 95-102 This Article

FATAL ACUTE CHLOROQUINE POISONING IN CHILDREN
Howard M. Cann M.D.1 and Henry L. Verhulst M.S.1

1 National Clearinghouse for Poison Control Centers, Accident Prevention Program, Public Health Service, U. S. Department of Health, Education, and Welfare
Four cases of acute chloroquine poisoning in children are presented. In three instances death occurred within 2 hours of ingestion of larger than therapeutic amounts of the drug. The rapid occurrence of death in acute chloroquine poisoning is probably explained by complete and rapid absorption of the drug from the gastrointestinal tract resulting in high blood concentrations which depress vasomotor function and respiration. Cardiac arrest follows and may be caused by the direct myocardial action of chloroquine, to anoxia, or to both. The similarity of the manifestations of acute chloroquine poisoning and those of acute quinine and quinidine poisoning suggests that acute toxicity may be attributed to the quinoline ring portion of these drugs.

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I don't think that we are seeing extreme examples. But we may be seeing less extreme immediate reactions or reactions where the toxicity builds up over time.

Quinoline rings are know to cause neurotoxicity. There are theories about how that happens. One of the theories is about blocking connexins which are gap junction proteins in the brains.

I don't know how montelukast could be breaking up so that it causes toxicity. Or if the problem is the how rapidly the liver enzymes can metabolize it. But there is plenty, plenty, plenty of clinical evidence that there is a quinoline ring culprit somewhere in the picture. Or some by-product of that causing problems.

Somehow it was decided that montelukast did not have the safety issues that the other drugs in the same category have. See this.

"The starting point in the development of montelukast appears to be a quinoline-containing structure, likely identified as a weak random screening lead (Figure 3). The Merck group hypothesized that this molecule was mimicking the olefin backbone of cysLTs, and that the addition of mimics for the acid and peptide regions of LTD4, might improve its potency. As a first step, the dithioacetal linkage first seen in some SmithKline compounds was incorporated; this led to a compound with greatly increased in vitro potency but poor oral bioavailability. When one of the carboxylic acids was replaced by an amide, forming MK-571, the new antagonist had even greater potency and good efficacy following oral administration. The enantiomers were resolved to yield MK-679 (verlukast), a compound with better clinical effects than MK-571, but whose clinical development was stopped for safety reasons. Further structure-activity relationship studies led to the development of montelukast (16), an antagonist that appears free of the safety concerns plaguing earlier members of this series."

If we can find out why the earlier versions were not safe and how they thought fixed it, then maybe we can find out what is going on with the quinoline ring in some people.

I would be very surprised if the FDA will address our concerns. Why does it always seem like they wait for enough people to die like in Vioxx? Wasn't Vioxx responsible for thousands of deaths?

My Dr. prescribed Seasonale, but pharmacy gave me generic Jolessa. I've been taking it for 1 1/2 months and have been bleeding since after the 1st week. I have mass amounts of constant brown discharge and clotting with daily breakthrough bleeding. I get headaches, cramping, bloating, light headed and dizzy episodes, and my mood has been edgy (maybe from a sexless marriage due to these pills, lol). I've been taking bc for 16 years and have never experienced these symptoms with any other pill I've taken.

Spoke with my doctor's office a few weeks ago and was told that the bleeding can be normal and don't be surprised if it lasts for 2 WHOLE CYCLES that is 6 months of bleeding and clotting! I know what is normal for my body and this is not it! I'm calling my doctor for the 2nd time today and will demand my prescription be changed to either the name brand Seasonale (which my ins will cover) or my previous pill.

Found this site and read the postings for the first time today. I cried when I read the first posting because it was as though I had written it myself. I have experienced so many of the negative side effects such as, depression, apathy, loss of sex drive, crying almost every day, anger for no reason, pain, and more. I am 38 years old and have been using the ring for almost 2 years. I took it out today as soon as I finished reading other's experiences. I am looking forward to being my "old" self soon, and I know my husband and children are too.
Maybe the side effects are worse for women in their 30's and 40's versus 20's. Not everyone posted their age but I was curious regarding this possibility.

I was just prescribed the Imitrex nasal spray. I took it for the first time today. The first thing that happened was my nose felt like it was on fire then i had a horrible bitter taste in my mouth and the back of my throat. About 10mins after i took it i throw up and my stomach started to hurt. Plus the bitter taste was still there and nothing but time made it go away. My headache went away true enough but I would rather suffer a migraine then go through that again. And my headache came back not too long afterwards.

I took 25 mg of Toprol for the first time today for high blood pressure and a high heart rate. I also have mitral valve regurgitation. Already, I can tell that I'm in a fog, very tired, and my chest hurts. I even took a nap around 4:00 pm today, and had a terrible dream. My hand and feet have been freezing cold too. Is it safe to stop taking this medication, since I have only taken 1 pill? I want to call my Doctor tomorrow. Thanks!!!

Jeannie

I am taking Adderall for the first time today, for ADD-like (inattentive rather than hyperactive) executive function symptoms resulting from a brain injury (frontal, especial left frontal, and temporal lobes) I sustained 8 years ago. I have had extremely bad problems with productivity ever since. I am a twentysomething female, 5'8" and 135lb and I took 10 MG an hour ago. I would say I am feeling unusually alert for this time in the morning, senses feeling more "awake," my heart rate a little elevated but not too abnormal, and also in a particular sense feeling calmer/less anxious than ordinary. I feel less compulsion to websurf, which is something I have a serious problem with. I'd say I am also finding it easier and smoother to compose this writing than I would ordinarily, I am hyper-literate and have a strong desire to write, but writing is usually like pulling teeth--very slow and very hard to organize my thoughts. I am starting to feel a buzz; I find a caffeine buzz very unpleasant and distracting, and caffeine doesn't seem to help my attentiveness and productivity all that much. But I am more alert and focused, and that part feels good. It is so tiresome and frustrating feeling "lazy," unfocused, foggy, and restless like I normally do. The buzz I am feeling is getting a little more intense and my heart rate also up a little more, I feel kind of tingly. I kind of don't like it and time will tell how much it bothers me after I am more used to it. I suspect that I may find it a reasonable trade-off to feeling focused. And again, in a particular sense I feel more peaceful than normal because I'm not having the stray thoughts and spacyness I normally do. That feels like a relief. I think I can see why people eat less on this drug, because of the heightened physiological state and the reduced feelings of boredom or restlessness that often drive people to eat. If I can use it to eat less sweets that could be good, but I will try to be careful to keep eating regular healthy meals. It's now an hour and a half since I took the pill and I think the effect is perhaps plateauing. My sinuses feel very clear and my mouth is perhaps a little dry. I was a little afraid to take this thing but the buzz feeling is probably not quite as bad as I feel after a 12 oz cup of black coffee and much less bad than a bad dose of nighttime cold medicine I had once, and with more benefit. I'm going to leave this posting at that and see what more I can get done today. Hopefully these observations help someone.

To the 15 year old wondering whether he/she should take Adderall, this is something you can/should ONLY decide together with a doctor. The doctor will be able to give you much better advice than anyone on the internet. Seriously. But if it puts your mind at ease any, you should know that underweight, unless it is extreme, is not in itself a serious health risk. If being underweight makes you self-conscious that is also a consideration, but a doctor can probably help you somewhat to manage your weight whether or not you take a stimulant.

hi all again

this is week 5 of yasmin now

i am feeling loads better in myself my anxiety and panic attacks are not like they were my anxiety is loads better and my panic attacks are mild now.

i went on hokiday for 4 day with my husband and oldest son whos 5 and had the best time ever that helped loads and i was not to bad felt a bit nervous in restaurnats and the showbar in the caravan site but after a couple of beers i was ok the nights were getting better as the week went on.

did me the world of good .
i was 3 weeks late on my period and the morning i come on i just changed i felt so horrible and i was so nasty and felt like i didnt want anyone around me i was snapping at my family so in the end went to bed out the way i think it really has affected me big time around this time, today my chest is playing up a bit feel like i have alot of wind today and i was a bit out of breath too very tierd also maybe this is because i have seen a period which i think is good as some women dont for months after coming of this

my left arm has been playing up a bit also today i think im gonna get a early night and see how i am tomorrow
i still get up in the night to the toliot

anyway anyone whos in the same stage as me let me know or anyone who has been of this horrible pill have u got better yet and how long till ur 100% normal thanks nicola

I was prescribed levaquin for a sinus infection. I have experience acid stomach, sweats(no fever), sleeplessness, but I'm exhausted and way too much energy at the same time. Today I've been so sick to my stomach so I thought I'd look up the side effects and here I am...stopping this med!!!!