Tissues symptoms and conditions

Hi everyone,

i need to tell you about what just happened to me, because it seems most people are definitely not informed of all the possible side effects of prednisone - not only just relating to the dose of prednisone you take but also for how long.

I have been using prednisone for almost 14 years now, the doctors all tell me i'm unlikely to ever get off prednisone now because i've been on it too long. I know all about it's usual side effects (water retention, mood swings, thinning of all tissues including blood, acne, anemia, etc etc).

One side effect i was not advised of, not even in any educational material about prednisone either, was that long-term dependence can lead to Acute Adrenal Crisis. Which is deadly if not diagnosed and treated promptly. Thus i nearly died two weeks ago. I became rapidly ill with vague symptoms that i now know are symptoms of acute adrenal crisis. *THE ONLY REASON THE ACUTE ADRENAL CRISIS OCCURRED WAS BECAUSE OF LONG-TERM USE OF PREDNISONE*. Not many doctors will warn patients in advance of this. It is however, very very important that people are aware that long-term use of prednisone needs to be very carefully weighed with the benefits of using prednisone (i was started on prednisone in 1995 to treat severe Crohn's Disease).

Acute adrenal crisis can happen over weeks, months or years - in other words, it can come on so slowly that by the time you know there's something wrong you're already very very ill and in great danger.

I am very glad to have found this website and i hope you will all refer anyone who has any experience with prednisone to this site - education and knowledge is power - the power to stay alive.

(by the way, the treatment for acute adrenal crisis is to load up on prednisone - seems i'll probably never be free of this drug unless i can get my adrenal glands to begin working again (as prednisone "takes over" for the adrenal glands and they effectively go to sleep, and this is especially true for long-term use)).

My sympathies to everyone who has to go through the many nasty experiences with prednisone, especially the young children (I had to start it when i was 16). It really does mess with your body and mind, and in my case, became lethal.

Please pass on all your information relating to use of prednisone to everyone you can - it really is that important and seems to be the only way to avoid most of the disasters related to prednisone use.

take care everyone,
Linda
(Australia)

Sorry, I can't just walk away.

When you find patents or patent applications for certain purposes, then you know that your ideas are well founded. There are several patents for using an anti-malaria drug for asthma. I would bet that somebody had that idea all the way back to the 1960's. So it is very possibly no coincidence at all that a chloroquinoline or other quinoline ring would be part of montelukast's chemical structure.

Here is one of the patents.

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It is well known that quinoline rings can be toxic to some people even very rapidly. As in this very extreme example.
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PEDIATRICS Vol. 27 No. 1 January 1961, pp. 95-102 This Article

FATAL ACUTE CHLOROQUINE POISONING IN CHILDREN
Howard M. Cann M.D.1 and Henry L. Verhulst M.S.1

1 National Clearinghouse for Poison Control Centers, Accident Prevention Program, Public Health Service, U. S. Department of Health, Education, and Welfare
Four cases of acute chloroquine poisoning in children are presented. In three instances death occurred within 2 hours of ingestion of larger than therapeutic amounts of the drug. The rapid occurrence of death in acute chloroquine poisoning is probably explained by complete and rapid absorption of the drug from the gastrointestinal tract resulting in high blood concentrations which depress vasomotor function and respiration. Cardiac arrest follows and may be caused by the direct myocardial action of chloroquine, to anoxia, or to both. The similarity of the manifestations of acute chloroquine poisoning and those of acute quinine and quinidine poisoning suggests that acute toxicity may be attributed to the quinoline ring portion of these drugs.

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I don't think that we are seeing extreme examples. But we may be seeing less extreme immediate reactions or reactions where the toxicity builds up over time.

Quinoline rings are know to cause neurotoxicity. There are theories about how that happens. One of the theories is about blocking connexins which are gap junction proteins in the brains.

I don't know how montelukast could be breaking up so that it causes toxicity. Or if the problem is the how rapidly the liver enzymes can metabolize it. But there is plenty, plenty, plenty of clinical evidence that there is a quinoline ring culprit somewhere in the picture. Or some by-product of that causing problems.

Somehow it was decided that montelukast did not have the safety issues that the other drugs in the same category have. See this.

"The starting point in the development of montelukast appears to be a quinoline-containing structure, likely identified as a weak random screening lead (Figure 3). The Merck group hypothesized that this molecule was mimicking the olefin backbone of cysLTs, and that the addition of mimics for the acid and peptide regions of LTD4, might improve its potency. As a first step, the dithioacetal linkage first seen in some SmithKline compounds was incorporated; this led to a compound with greatly increased in vitro potency but poor oral bioavailability. When one of the carboxylic acids was replaced by an amide, forming MK-571, the new antagonist had even greater potency and good efficacy following oral administration. The enantiomers were resolved to yield MK-679 (verlukast), a compound with better clinical effects than MK-571, but whose clinical development was stopped for safety reasons. Further structure-activity relationship studies led to the development of montelukast (16), an antagonist that appears free of the safety concerns plaguing earlier members of this series."

If we can find out why the earlier versions were not safe and how they thought fixed it, then maybe we can find out what is going on with the quinoline ring in some people.

I would be very surprised if the FDA will address our concerns. Why does it always seem like they wait for enough people to die like in Vioxx? Wasn't Vioxx responsible for thousands of deaths?

I took my 16 year old child off of singulair 6 weeks ago (3-28-2008). She started taking it 11-17-2003. She became dark, depressed, grades dropped, dropped out of dance and cheerleading, started cutting her legs with razors, stomachaches, headaches, anxiety attacks, trips to the emergency room. 6 months of fluoxetine given by her psychiatrist. Nothing helped her be happy again. Sad and Dark young woman. NOW: She smiles a lot, and is eating diner with the family. No headache or stomachache for a month now. She is sleeping better. Before she said that her mind would not stop thinking. She is taking pictures again and even asked me to order her book called "Understanding Exposure" and is talking about taking a class on digital photography at NMSU branch university to start on her college electives now. She is out more and even has a part time job at an ice cream parlor. Just lately I have stopped checking the trash for waded up tissues with blood (from cutting). Chris, I have had all her medical records sent to her primary Doctor and we are very willing to open them up. You have to have a child suffering to understand where we are coming from. The most dangerous place on earth is standing between a mother and her child. Singulair took our children from us and maybe changed them in some way forever.

I received the Kenalog shot in January. I started feeling tired and muscle aches, which I thought was just a virus. Then a dent appeared on my arm 2 weeks ago, and my muscles surrounding the maroon color dent began to tighten. I now have tendinitis in my shoulder and arm and I have lost all strength. My doctor said it could be from the shot, but stopped seeing me. i am going for an MRI on Monday because of the damage and pain that is non stop, and they are trying to figure out what is wrong. I have had several blood test because they swore I must have Lupus, or Rheumatory arthritis which came back negative.
I am very frustrated. I am a server by trait, I am a mother of 5, and it seems like my life is changed. I can't work, no one can give me answers, and I would like to know if these symptoms will go away or if I am stuck with this arm atrophy forever.

I've had a "dent" for about four years now, and had no idea what it was until now. I'm relieved to find out that it isn't anything like cancer.....but will it ever go away? Are there any known treatments or cures?
I'm very upset that my doctor gave me no warning of side effects of the Kenalog shot. I was only told that it would aid in my relief from allergies. I have now received the shot for five years in a row, and have two "dents" on either side of my lower back. Any advice on legal action?????

I had a Kenalog shot about 6 weeks ago in my face for what my doctor thought was swollen tissue after a surgery, however the Kenalog has eaten away at my tissue creating a "dent" in the side of my face. This has been a really terrible and frightening experience, and I am very concerned that the tissues will not regenerate themselves over time. He has told me that it could take a year for the tissues to regenerate themselves. Please, anyone out there who has had a similar experience with tissue atrophy after a Kenalog shot, please would you let me know if this tissues really ever came back gradually? Thanks so much.

Hello, everyone. I didn't know there was a page like this, but I'm glad there is. I've been on Topamax for 3 weeks because the medicine I was on for 2 years didn't do anything and the headaches weren't going away at all anymore; they were continuous. The first week at 25 mg I had the tingling for a day or two, the involuntary muscle twitches, the terrible mouth taste, and the chest pain. All but the terrible taste went away by the second week at 50 mg but I started getting wobbly legs and dropsy. I read an article somewhere where a person on Tomamax called the drug Stupamax or Dopamax and said anyone on it turned into a box of rocks. The box hit me at 3 weeks and 75 mg. I'm not wobbly anymore, I'm still irritatingly dropsy, and I am doing things that only a person with half a brain would do. Plus, my ears have been ringing for two days, and today I feel like I'm in a tunnel and everything is far away. I'm getting ready to call my doctor. On the OTHER hand, I haven't had a headache that lasted for more than a half hour in 3 weeks. So what's best? Going back to headaches or continue to evolve into a box of rocks?

I was a 2:42 marathoner. I used a synthetic varnish containing isocyanates, pentanedione, organic solvents, in one 7-hour session; the company-recommended respirator did not in fact prevent transmission: Severe chemically- induced asthma, plus neuropathy, plus, plus.

I've used Advair 500/50 for six years. There have been many diverse effects from the chemical exposure; I'd not questioned any being Advair side effects. But the raised blood pressure was not initial, and certainly not a priori. Diminished hearing, diminished eyesight, anxiety. Again, not to lump in, but these questions are new for me. But the point I'd like to bring before this group is this: In August I was diagnosed with ehlichiosis , and was prescribed 28 days on doxycycline. They recommend eliminating many possible antagonists to the doxycycline. My respiratory capacity had been continually diminishing. My ongoing physician said this was to be expected and recommended only the next more powerful steroid. Not a good solution. Before all this I was strong; repaired myself. In the absence of constructive answers, wondering if the Advair was weakening me, making me dependent, I quit the Advair as well on beginning the doxycycline. Today is eleven days post-doxycycline. Eight days ago there began with increasing severity, a terrible wracking deep cough producing dark yellow mucus. Painful. No fever. Grevious throat from the wracking, but I question whether this is a cold or infection. It's just in my lungs. Maybe it's as though I've thrown off an epithelial coating. These past two days the quantity of deep yellow mucus is not as ready, but the wracking and coughing is more severe. And my lung capacity, my respiratory capacity, is frighteningly diminished. Until these past two days I'd considered this an infection, especially post-doxy. But it doesn't feel like an infection. And I'm scared. Is this because I quit the Advair abruptly after long regular use? Have any of you had a similar experience. Can you discuss the effects of abruptly discontinuing Advair. Have you stayed off it. What's happened to your respiratory capacity. Have you any professional studies, trials or experience to recommend. Thanks.

This is a nightmare. I have been on Lamictal 200 mg, tab in morning, for approx. 5 months. About 3 1/2 months ago I started getting muscles aches and weakness, muscle overuse problems, fluid retention ( like 12 pounds), stayed in a trance with very little short term memory. Thought it was everything but this medicine....I am an avid athelite, yes, even at 51. So, I blamed myself for not slowing down. Quick exercising totally, for 2 months, iced 3 times a day on leg muscles. Finally after making it to the summer without a mental breakdown, I went to the emergency room and a new internist to get checked out. Blood work, thyroid, hormones,ok.... Really don't care what they think , I can not walk, it hurts like hell. The Dr. did tell me to get off Lamictal....ok 7th day and I have some relief but it is not complete. Called manufactures, interesting, yes- these are side effects!!! But the studies are limited. Listen , unless you have seizures, get off this medicine... you read the full disclosure of side effects and then search yourself......It can ba a huge FOOOOOPA.....And you are the fool that will end up holdling the bag, not the manufacturer. Hopefully I will get better. Right now , I just trying to stay calm.

My joints all over my body are painful. I don not know if it is a side effect of lithium because I take other medications. The drugs include femara, niravam, cymbalta, famvir, calcium 1000 mg., a multivitamin capsule, glucousimine, echinacea. please give me some advise as to why I get veryt painful joints and the back of my neck pops constantly throughout the day.

We made an entry regarding our then 3 1/2 year old son in Oct, then Dec of last year. It has been approximately 5 months since we removed our son from the use of singulair, after a year of use. He now stammers a bit, as opposed to severe stuttering, and his aggressive behavior is greatly diminished, though he does still have episodes, both noted in particular when he is going through or immediately following growth spurts. I begin to feel that we may never totally regain our little guy as far as his serenity is concerned, but the differences between last fall when we removed him from his medication and now are remarkable. What has totally returned is his ability to concentrate. Any excess energy is now easily channeled into dancing, jumping, wrestling, and playing music. I Thank God that in the last couple of months, he has once again expressed interests on his own accord in regards to wanting to develop friendships and enjoying the playtimes he experiences with other children.
Is there any physician that would be able to state how long singulair remains in the tissues? My concern is in regards to the occassional outbursts of anger or sudden depression. I will be seeing his doctor this month for his annual exam and will be discussing the symptoms I still observe.

there are many adverse effects individuals feel are attributable to statins that do not reverse with stopping the drug--neurological adverse effects from nerve involvement, such as periphral neuropathy. The damage done to the nerves may be permanent damage and not reversible with "tincture of time". In addition, the "tissue half life" of a statin is unknown (amount of time required for half the drug to be out of the tissues)--could be months or even longer. thus even if the symptoms do not disappear within a weeks' time does not exonerate the drug as the cause of the symptom(s)

My legs swelled immediately upon taking Levaquin with pain also in the tissues of my legs and not the joints. Breathing problems also accompanied the leg swelling. 5 months after taking Levaquin my legs are still swollen with pain and I can not take a deep breath. My oxygen level is only 94. Any advice on a cure would be greatly appreciated.

This company who makes Wellbutrin also made a drug called advair (for asthma). This info may help..........

I am not a specialist. All I did was look up as much information as I could after the Medical Doctors told me advair
couldn't cause these side effects and it doesn't cause an auto-immune problem.

YOU ARE EXPERIENCING PROBLEMS OTHERS MAY NOT UNDERSTAND!!!

Candida is always looking for a chance to grow and spread. It can CHANGE ITS FORM in different ways. It can change itself to resist certain substances you take to eliminate it.

Thyroid:

Thyroid gland is located in lower front of your neck. It makes thyroid hormone, which is secreted into the blood and then carried to every tissue in the body. It is essential for helping each cell in each tissue and organ to work right. Thyroid hormone helps the body use energy, stay warm and keep the brain, heart, muscle and other organs working, as they should. A malfunctioning thyroid and a compromised immune system can make you more sensitive to any common allergens. This combination can also produce numerous other harmful side effects including WEIGHT CONTROL.

Fungus:

When antibodies form to attack the pathogens, the pathogens can often take on a similar appearance or likeness to the various tissues they attach themselves to (THYROID tissue, HEART tissue, LUNG tissue, MUSCLE tissue, etc.) When this happens, the antibodies will attack the pathogens along with the tissues of the organ, lining or whatever they attach themselves to. This can lead to various kinds of allergic reactions and medical complications of all kinds. This fungus (candida) can also produce a waste product called acetaldehyde, which produces ethanol. This minimizes your body to assimilate iron. This decreases the amount of oxygen in your blood. This reduces the chances for oxygen to get into your individual cells. Ethanol wipes out enzymes that are necessary for individual cell energy.

Leaky Gut Syndrome:

Hair-like roots tunnel their way through the small intestinal wall, working their way into the blood stream itself. Partially digested food particles can enter the blood stream. After a certain point your liver will no longer be able to filter out these food particles and TOXINS from re-circulating through your body by means of your blood. When food particles travel through your blood, they become like foreign invaders in your body. Your immune system will respond to this attack in various ways. At this time, your body can begin to experience reoccuring complications simply on the foods you eat, things you drink and even supplements you take.

Use the web and do the same. It's amazing how much info you can find. And once again, if you know of anyone who was prescribed advair and you feel the same way as I do about the product, handle it the best way you know possible. I have yet to figure out how to undo the damage.

Best of luck.

Side Effects from Advair: Guest #4309 again Also look at response #7070 written on Sept 11 just below.

I am not a specialist. All I did was look up as much information as I could after the Medical Doctors told me advair couldn't cause these side effects and it doesn't cause an auto-immune problem.

YOU ARE EXPERIENCING PROBLEMS OTHERS MAY NOT UNDERSTAND!!!

Candida is always looking for a chance to grow and spread. It can CHANGE ITS FORM in different ways. It can change itself to resist certain substances you take to eliminate it.

Thyroid:

Thyroid gland is located in lower front of your neck. It makes thyroid hormone, which is secreted into the blood and then carried to every tissue in the body. It is essential for helping each cell in each tissue and organ to work right. Thyroid hormone helps the body use energy, stay warm and keep the brain, heart, muscle and other organs working, as they should. A malfunctioning thyroid and a compromised immune system can make you more sensitive to any common allergens. This combination can also produce numerous other harmful side effects including WEIGHT CONTROL.

Fungus:

When antibodies form to attack the pathogens, the pathogens can often take on a similar appearance or likeness to the various tissues they attach themselves to (THYROID tissue, HEART tissue, LUNG tissue, MUSCLE tissue, etc.) When this happens, the antibodies will attack the pathogens along with the tissues of the organ, lining or whatever they attach themselves to. This can lead to various kinds of allergic reactions and medical complications of all kinds. This fungus (candida) can also produce a waste product called acetaldehyde, which produces ethanol. This minimizes your body to assimilate iron. This decreases the amount of oxygen in your blood. This reduces the chances for oxygen to get into your individual cells. Ethanol wipes out enzymes that are necessary for individual cell energy.

Leaky Gut Syndrome:

Hair-like roots tunnel their way through the small intestinal wall, working their way into the blood stream itself. Partially digested food particles can enter the blood stream. After a certain point your liver will no longer be able to filter out these food particles and TOXINS from re-circulating through your body by means of your blood. When food particles travel through your blood, they become like foreign invaders in your body. Your immune system will respond to this attack in various ways. At this time, your body can begin to experience reoccuring complications simply on the foods you eat, things you drink and even supplements you take.

Use the web and do the same. It's amazing how much info you can find. And once again, if you know of anyone who was prescribed advair and you feel the same way as I do about the product, handle it the best way you know possible. I have yet to figure out how to undo the damage.

Best of luck.