May 6th
2008
6:52 PM
We have all been saying that our issues regard not being informed about all of the possible side effects. And, we know that Singulair works well for some people. Nobody wants to take a good drug away from those for which it probably performs miracles. People who have toxic side effects have a right to know up front.
My observations about montelukast's chemical structure are either general or not quite 100% correct or could be quite vague - so forgive me. I do not claim to be good at organic chemistry. But from doing a little work, I have come up with some observations.
1. It would seem to me that montelukast might work quite well for people who have developed mold category related asthma. I observed that chloroquinolin, a component of montelukast, is a good fungicide effective against Aspergillus, Alternaria, Cladosporium, Penicillium and Candida. Dust mites can only digest if helped by aspergillus so they go into the mold category. Molds produce millions of spores so anyone who lives in contact with mold would be chronically sick from their presence. Then people get hypersensitized to that.
I am probably wrong but I could imagine that montelukast is: 1) a ligand that binds to an empty cysLT1 receptor for a period of time 2) 7-chloroquinolin-2-yl which either acts intact or breaks down into a quinoline fungicide so that it kills the chronic mold/fungus infection and 3) a sulphur/methyl anti-inflammatory component that tells the t-cells that they are not needed so they will die. Wow, that would be great for mold asthma if it was completely non-toxic. It would be also great under controlled circumstances for many people who are mold-miserable. If I am wrong, I better go out into my garage and start inventing such a drug.
This is my visualization to try to explain the side effects of neurotoxicity. So adverse reactions could be to the quinoline component as an allergic reaction or dose related so that it just built up to a toxic level over time. There are many signs that t-cell populations are significantly reduced by montelukast. The fact that the Italians can do it in the test tube might be that it's a chemical component of montelukast designed to cause the t-cells to die.
Montelukast is a large molecule so Artie says it cannot penetrate the blood brain barrier. That would be an argument if nobody was complaining about neuro-psychiatric side effects. The neuro-psychiatric side effects are identical to quinoline and quinolones. When I read about Lariam, it just sounds like a more extreme version of Singulair side effects. Chloroquinolins were used before they invented Lariam, which is stronger. The malaria Plasmodiums became immune. Hallucinations, anxiety, depression, suicidal thoughts are completely consistent in all of the quinoline/quinolones. If montelukast breaks into sub-molecules then quinolines easily penetrate the blood brain barrier.
I find clinical evidence that montelukast may act as more than more molecule. And, that there is a rational for the existence of the chloroquinolin and evidence that it may be the source of toxicity.
I am glad to risk being called crazy. That is what the internet is for. We can present our ideas and discuss. So, just take this with a grain of salt. If I am close to the truth, this post will find it's proper home.
-- By concernedcitizen | Reply | (12) replies | Private Message me
November 24th
2004
12:28 PM
I can't believe Levaquin was approved by the FDA! I was prescribed levaquin for a sinus infection and after 5 days I woke up unable to move my neck or shoulders without severe pain. I am 57 and in good shape, or was in good shape. It has been a week since I stopped taking the drug and I am still in so much pain I can't lift weights or swing a golf club. My shoulder feels like it is coming apart at the joint. I'm married to a doctor and he is also amazed at the toxic side effects of this drug.
-- By mdaven99 | Reply | Private Message me
October 10th
2004
4:34 PM
i've been on tegretol for well over 15 years now, for my Status Epilepticus (severe epilepsy). i was always on a small dose (600mg daily i think). but due to my epilepsy being poorly controlled, the dose got increased to 800mg - that was around 10yrs ago.
i am 6' 5", and used to weigh around 224 pounds. Since the dosage was upped to 800mg/day, i have gained around 84 pounds in weight, and have allways had drowsiness, lack of concentration, poor short-term memory, double vision and terrible balance. And still the epilepsy has been poorly controlled, still suffering petitmal and grandmal seizures.
So around a month ago, my neurologist was informed of my side effects becoming so severe. He told me they are "toxic side effects" of the tegretol.. Yet told me to increase the dose, by 200mg/day, increasing it every fortnight.
i.e. up to 1000mg/day, then 2 weeks later go up to 1200mg/day, etc.. he told me to keep doing this till i get to 1600mg/day. then possibly go as high as 2000mg/day.. !!
i have to tell you all, that since i started following his advice and increasing the dosage past 1000mg, i have felt absolutely terrible. I find myself needing over 13hrs sleep, then more sleep a few hours later. I also have difficulty reading (despite my eyesight testing ok), and unbearable migraine-style headaches.
at 30years old, my daily routine is not too good at present. And still no benefits have been noticed since upping the dose. On 13th October, i increase it to 1400mg/daily.. :(
-- By austin_316 | Reply | Private Message me
November 7th
2009
10:51 PM
I'm a 70 year old woman, I have taken this drug for 3 1/2 yrs. I was prescribed Spironolactone 25mg for high blood pressure of 140/80. After researching the side effects I chose to stop taking this drug 2 days ago. First off, it's a potassium sparing diuretic and one isn't supposed to eat foods high in potassium, like fruits and vegetables a contradiction to what is needed for both high cholesterol and high blood pressure, does this makes sense no it doesn't. Also I was taking a potassium supplement, maybe I'm lucky to still be alive?
-- By dorothy100 | Reply | Private Message meI don't think Dr.'s read about side effects or what one isn't supposed to eat or take along with the drugs they prescribe. They only look at what the drug is supposed to do, then prescribe it to thousands of patients their, victims. This is probably why they're considered, "Practicing Physicians!"
This drug is known to cancer. This drug is known to cause muscle pains. This drug has caused me to go Bald on the top of my head. This drug plays with ones hormonal balance, it can help make someone grow hair, or lose it. This drug should not be prescribed for simple high blood pressure, it is a very dangerous drug!
I have huge rashes on my ankle and now my hands, they say it's eczema or drug induced atopic dermatitis.
Please do yourself a favor and research the many side effects and cancer causing of this drug. If you're taking simply to lower your blood pressure find a safer drug and try to stop taking this one particular diuretic and use supplements and foods to lower it if you can.
I'm taking this and Lipitor which I stopped one week ago and this one two days ago thank God, I thought I was going to be a cripple for the rest of me life from the toxic side effects, all drug induced.