Urgency symptoms and conditions

I have been on Flomax less than a week. Already I am seeing signs of mental confusion, being drowsy to the point of almost falling asleep at inopportune times, muscle cramps, and a dull ache in the area of the prostate.

Flow was good prior to starting Flomax. It has improved slightly but so has a sense of urgency. It seems to be acting a bit like a diuretic in that I am going a lot more frequently and with high volume and good pressure.

Diuretics can cause a loss of potassium, which can result in severe muscle cramps or spasm. I have had a charley horse in the calf, a foot that cramped up when I stood on it, and a tightening of the abdomen such that I could see a lump in one area. One must wonder if these are related.

The precautions include watching for heard palpitations. The heart is a muscle, isn't it? I would not want that muscle cramping up.

Perhaps the doctor thinks it advisable to attain perfection in urinary performance. But perhaps it is better to go through life with a slight problem that will likely not change, and also without irritating a gland that is prone to cancer. In reading the postings here it would seem that this medical perfection comes at a great cost.

The only medication i take is Wellbutrin Xl low dosage. I don't know if this is actually FROM the Wellbutrin, but about 9 months ago, i developed urinary tract symptoms of chronic urination. I have to go to the bathroom dozens of times a day , and at night I get up 6-7 times to pee. Full bladder pees.
I do drink more water during the day, as i get dry mouth from the medication, but this is not just related to water, because if i stop drinking more water, this will still occur. I'm in good health and my doctor told me I am too young to have urinary dysfunctions that come in older age. There is nothing found by ultrasounds. I Was wondering if anyone else on WELLBUTRIN XL is experiencing this as well. Also, recently I had a sudden increase in my blood pressure. I don't have a history of this.
I am 49 yrs old, white female and in generally good health.
I would not fail to mention that Wellbutrin XL is an excellent Antidepressant, the best of any of the others i have tried over the years. I am almost fully functioning, but still working on my issues.
I actually have felt emotions that were happy and positive on a recent basis after many years of "numbness". this drug has not had any headaches, anxiety causing, that wheel spinning or disorientation those other antidepressants had for me. I had to stop taking more than 8 different antidepressants in the past.
I'm just mostly wondering about urinary dysfunction issues. Please post if you are using this and having this.

60 YO male: three weeks on .4 Flomax

I went on it because after Parathyroid surgery for kidney stones, I was still having symptoms. Mostly a painful urgency to pee, with only tablespoons coming out. That would last for 3-6 hours. I started out with pyridium (the pill that turns your urine orange). That seemed to help, but I was still having some lower-right abdomen KS pain events with the urgency. The urologist suspects I still have some stones that have yet to come out.

My prostate exam and PSA were good. No signs of cancer. I don't think the size of the prostrate was measured or whether BPH was an issue because of the obvious Parathyroid issue.

I started taking .4 Flomax, got the lightheadedness that evolved into a feeling of being slightly high most of the time. And feeling mildly relaxed.
Flow was improved, maybe a few less pees per day. Still peeing at least twice a night; good stream, good quantity.

Not a runny nose, but a thicker discharge. This week (3 weeks in) the nose is better.

Lower volume and clearer ejaculate. After the last ejaculation, I went right into an urgency and lower right KS pain event that lasted 6 hours. I was uncomfortable, but OK on Tylenol and pyridium. My events frequently happen on Saturday/Sunday. I have tried to figure out what, if anything I might be doing to cause or break this cycle, but there seems to be no correlation. I was hoping to get rid of the painful and disruptive urgency episodes, but so far they are still here every week or so.

Dreams have been a bit weird.

I have a swollen knee and toe, but this could be due to some hiking while on vacation. I saw the posts about painful joints, but can't make a direct connection yet.

Since Flomax three weeks ago, there seems to be a low level feeling in my lower abdomen. Not a pain as much as a presence, a tension. I think it's in the testicles, but you know how that is; accidentally smack one and the pain feels like it's inside the body.

Hi, njcukett posted 2 days ago asking if anyone is still having abdominal pain after being off singuliar awhile.My 7 yr.old (on singuliar at least 3 yrs.) is still having pain.She also had bladder issues for the past 2 yrs.(Frequent dripping and urgency to void).This went unexplained by doctors.Over the past 6 weeks since she stopped taking singuliar,I have noticed a complete change in her stools.While on singuliar they had become grayish in color.She would have 2-3 of these movements a day.The color of her stools are now normal,but the lower abdominal pain is still present.So I am wondering if the pain is coming from the bladder, not the stomach.I am going in(without my daughter) to discuss this with her pediatrician next week.Singuliar also made her very anxious,do not want to add to that,by discussing this in front of her.For the people having abdominal pain,did the stools change while on singuliar compared to when off?Just curious.

I spent the weekend reading about the development of Singulair. The early studies recognized that the first phase of the acute asthma response bronco-constriction was probably not caused by leukotrienes. They identified histamines and prostaglandins as the probable sources. I don't think that changed because the Singulair literature states that it should not be considered as a treatment for that. Leukotrienes were a source of inflammation caused by eosinophils and mast cells present in greater numbers (than normal) in airway tissue. So, it was beneficial to find a way to decrease that.

The cysLT1 receptor was identified as source of the signals that tell the cells to produce leukotriene. The receptor, a gene, consist of 337 (they think) amino acids. They modified a compound that would bind to that receptor thus blocking the cells ability to produce leukotrienes. This compound is very specific. It was formulated to bind to the "model" receptor. This compound will not even bind to cysLT receptor sub-types. (That is the good thing.) There is an enormous amount of research that discusses the genetic variability of the chemical reactions that occur in the leukotriene (calling it this for simplicity) pathway. We are also seeing that a number of researchers would like to use gene profiles to predict whether patients will respond favorably to different asthma/allergy drugs. ALL PATIENTS HAVE A RIGHT TO KNOW IF IT IS INHERENT THAT SOME PEOPLE WILL NOT RESPOND TO SINGULAIR OR RESPOND ADVERSELY.

There are many studies from the 1998 era that conclude that montelukast is not effective for everyone. Those researchers stated that it can be predicted that those people who are going to respond favorably will do that within the first 14 days or so. That conclusion would be consistent with a genetic component for efficacy and safety of Singulair. Those doctors concluded that those who did not respond within that time frame should not take Singulair for fear of harming them. That makes good sense.

The Italian researchers wanted to know if there was more going on than blocking leukotrienes in the action of montelukast. They set up a "test tube" study regarding montelukast, the cysLT1 receptor, and some t-cells that they selected. Why? Researchers always have something on their minds. They observed the death of these particular t-cells.

Montelukast is a quinoline. We basically know of quinilines and quinolones as compounds that were invented as broad spectrum antibiotics. They work because they interference with bacterial DNA so they cannot replicate themselves. Montelukast is a quinoline modified to bind with the cysLT1 receptor (a gene) and prevent that gene from activating. That's consistent with what a quinoline/quinolone does.

So what does montelukast do in blood plasma if it does not bind to the receptor because of genetic mis-match? (If montelukast does bind, then a chemical reaction has occurred and the liver will break down the by-products. Montelukast metabolized in 10-12 hours.) What happens if it doesn't bind? How long before it breaks down? Does it produce toxic by-products?

I want to know what happens to lymphocytes such as t-cells just because montelukast is a quinoline. Maybe nothing but what's up with the Italians researchers? I want to know if montelukast has the capability to interfere with lymphocytes who can clone themselves. That could be a good thing under circumstances when these lymphocytes are causing inflammation. But it could be a bad thing in the case of normal individuals with no problems.

I want to know if the bad side effects are due to the fact that the body has to break down and metabolize a quinoline that did not bind to the receptor for which it was created. The side effects of Singulair are strangely similar to what is observed in the quinolones such as levaquin. I have not as yet been able to compare montelukast as a quinoline to levaquin as a quinolone. I am hoping to find something on these categories. There may be no reason to worry that they cause similar damage. But frankly, I think that there is. There is some terrible chit happening to some people. The scariest is the neurological damage.

All of these questions would be in the everybody pharma knows to ask category. I don't know where the answers are. I haven't found them as of yet. Maybe there are no answers. We have to remember that Singulair and Vioxx were released in the same year. They have continued to be drugs under the current executive management of Merck. If the Vioxx marketing promoters had their ghost writers, why not the Singulair marketing promoters. The genetic component appears to be widely accepted but we haven't heard one thing about even that.

I think that it is sad that maybe the marketing of Singulair as one stop shopping for asthma/allergies may have destroyed the original concept. I really think from reading the original work that they knew that they couldn't engineer a drug for one size fits all. Everybody gets harmed when information is withheld.

Shame on the allergist who yelled at the mother who wanted to discuss issues. Does he know exactly who is allergic to Singulair and who isn't? Get him a dunce hat. Just because Singulair is marketed for allergies does not mean that you cannot be allergic to it. See the power of Madison Avenue? The ad agencies focus group these drugs to death. The ad agencies cleverly craft the product information. A good piece of legislation would be to prohibit consumer drugs ads.

I've been taking Wellbutrin 200 mg at night for migraines, along with a low dose high blood pressure med in morning, these prescribed by my neurologist to combat migraines, which I was getting 15-20- times a month. I don't suffer depression or high blood pressure, but this seemed to work well for first 4-5 months. Only a few migraines in all that time, but she just increased me to 300 mg in morning instead because migraines are back. I had dry mouth, vivid nightmares, rapid heart beat that would wake me up middle of night, startled when I woke up, urgency to pee very often, them have to force it out, and have lost 10 pounds, which I didn't need to lose. Increased energy,less anxiety, and nightmares aren"t as bad, but am afraid will get worse on increased dose. But it worked for my migraines for 4-5 months wonderfully, and I've suffered for 20 years plus. Thought this might be helpful to someone out there>

I came across this site purely by entering "swollen red foot and kidney pain" into my search engine, imagine my shock when up came a site listing kidney pain and lisinopril!! I have been taking lisinopril for about 7 months now and as I had no adverse side effects in the first week carried on popping my "little lifesaver" no questions asked. Over the last 3 months I have experienced kidney pain to the extent that I was beginning to think I would pass a kidney stone! dry persistent cough, sleeplessness which means I am up at all hours throughout the night and catnapping (when I can) during the day, nausea ,stomach pain and headache!! The swollen foot I don't think I can attribute to the lisinopril....but who knows? I appreciate that in medicine we use various "poisons" as cures and remedies for illness, but when I read of the side effects that so many people are experiencing and am able to see a definite link to the ones I am experiencing then I start to wonder ....the good thing is that this drug and I take 10mg daily has reduced my B.P to a rather good level.....but I have decided to stop taking it for a few days to see whether my symptoms stop and have made an appointment to discuss this treatment with my G.P as a matter of urgency!! Thanks...Jill xx Oh almost forgot to add the incessant itching as well!!

I have been taking toprol xl for approximately 9 mos. It was givien to me for rapid heart beat. My dosage has been doubled twice so that I am on 50 mg. I hate this medicine. I still have some rapid heart beat, I wake up every two hours at night, my legs hurt, and I have gained 20 lbs. I also wonder if it is this medicine that makes me sweat profusely. When I am doing yard work, or anything else in the summer heat, the water just pours off of me. I have never been a heavy sweater and I am out of doors all of the time. I want to get off of this stuff. Can I wean myself off by lowering the dosage a week at a time?

Night sweats! Horrible! Depression and sadness, yes...but never linked it to the ring. On the ring for 7 weeks when experienced racing heart and shortness of breath. Friend who is a nurse suggested it could be related to the ring. So immediately I removed it. Started having horrible night sweats immediately and have continued practically every night for 2 weeks. Have had xray, ekg, blood tests....nothing abnormal found. Convinced it was from NR.

Started to get blurred vision, couldn't control urination,sleeplessness, muscle pain etc, quit taking and some urgency symtoms dissipated.

BELOW THE KNEE, LEG, FOOT,TOE CRAMPING. AND LOCKING, DRY MOUTH, CONSTANT THIRST, MORE FREQUENT URINATING AND URGENCY TO GET TO THE BATHROOM. SORT TERM MEMORY LOSS, SHORT SLEEP CYCLES, STRANGE DREAMS. ALWAYS TIRED.

I recently was diagnosed with IC 11/04 after getting a second opinion from another urologist. Thank god for my gut feeling.
I am now taking Elmiron (400 mg.) a day. once in the am and once after supper.
I must take it with a full stomach and lg. class of water. I experienced HEADACHES, alittle upset stomach. But I am worried about hair loss.
I found that the Elmiron has definitely treated my IC and my symptons almost vanished!! I don't have the pressure, pulling sensation, the urgency (remember???). I do still have a mild cystelole (sp.) but am seeing dr. regarding that.
I see my dr. in March for the first follow up. My prescription is for a year. I guess with diet and this Elmiron I should be better. I worry about medicine for the rest of my life. Any thoughts.
Thanks,

I just started taking desogen that i got from planned parenthood. and i'm really not happy with it, i'm on my second day and already I want to stop it. I want to give it time though. ..but right after i took the first pill i went to work and felt really really tired and depressed.likei wanted to crawl in a hole and quit everything . i noticed thati got upset about a couple of things quicker, and than today my second day i was exhausted all day, my eyes are dry and i feel extremely tired with a strong pressure headache. i'm gonna try to get thru the whole pack, but i don't think i can take this....also i don't know if this is related but i've been peeing ALOT more over the past two days..and with urgency. it's really yellow too.

bloating and weight gain...fortunately only occassional heartburn, sadness hits suddenly (again not often nor for any long period), frequent urination or sensation of urgency,
am at the moment decreasing dosage 1mg a week.