Wardrobe symptoms and conditions

I was put on Topamax for migraines about 4 1/2 yrs ago. I only took it for about 2 weeks. I was already under weight when I started taking it. I had horrible side affects. I could not even drink water without getting sick to my stomach. Every thing I ate soon left my body. I lost about 20 lbs in that 2 weeks. I had extreme fatigue. My mind seemed to be gone. I felt like I was crazy. My drive to work was about 25 minutes. I would get to work and forget how I even got there. I could not carry on conversations with people. My best friend got so worried that she stayed on me until I went back to the doctor to tell her my issues. She immediately took me off Topamax and switched me to Depakote. Depakote worked great but I gained so much weight that I had to buy an entire new wardrobe. So, I stopped taking it on my own and decided to just deal with the migraines. As much weight I have put on, I wouldn't mind getting back on Topamax and using it as a diet pill.

This website is a joke! After I had my Mirena inserted 4 months ago I started reading on the internet about possible side effects. I was furious with myself that I hadn't Read up on this before the appointment. There were so many horrible reviews involving hair loss, weight gain, acne, and mood swings! I was so scared and actually thought about removing the Mirena that week. I then found multiple reviews on websites not owned and operated by other drug companies that are trying to scare people in order to prevent the sale and use of the Mirena and the side effects listed here were a 180 degree difference. I have not experienced any weight gain, in fact, I recently was able to shed 5 pounds from picking up running again (so it is possible to LOSE weight on the Mirena as well). I have had zero hair loss, have not had a pimple anywhere or any random hair growth. My live in boyfriend and I have discussed if we've noticed any mood swings or changes and my mood which is usually optimistic and positive has been the same since I had the Mirena inserted. My periods are much lighter and although they can last an extra day or two more than what I was used to, they are light and I have not had any cramping. I'm writing this review not because I absolutely love the Mirena, I think it's a fine form of BC but who LOVES their BC, isn't it all kind of a pain. The Mirena is by far the most convenient form of birth control and I don't worry at all about missing a day and the chance of getting pregnant. I'm writing this review because I encourage everyone to talk more with their doctors about the side effects and look around on the internet for REAL websites.

I came to the conclusion myself, luckily, that Yaz was causing my weight gain. After having back surgery in April and gaining not a pound while not working out, I have been on Yaz for four months and I literally have gained 10 pounds in the past three weeks, my boobs hurt like when I was pregnant and I have even been lactating a little! Ugh! Sex drive...gone. Headaches, lack of motivation, could sleep ALL day. I took Yasmin for years and years with no problem at all. I recommend against this method of BC if you aren't taking it for a specific condition. It's just not worth the hassle OR a new wardrobe! I'm almost 40 years old, have been working out since I was in my teens and have not weighed this much since I was pregnant. I know that the trainers in my gym think i'm some kind of closet eater or something! I'm working and working and getting fatter!
The symptoms all are things I experienced while pregnant with my son - 18 years ago! If I wanted to feel preggers, I'd get preggers! My new husband probably thinks I'm letting myself go now that I'm married. Luckily he's very sweet and understanding. It was his idea to change my BC back. Call you doctor. Now!

I was diagnosed with pneumonia in Nov 2008. When I was released from the hospital, my doctor prescribed bactrim (2pills 3x daily).
After a short time I had noticed body aches and my legs and joints felt as if I had been hit with a bat.
The primary side effect was a rash like skin irritation all over my body.
What started as itchy red marks, began to dry up and my skin was flaky and hard (back, arms, chest, legs, stomach, neck, face and ears).
I was admitted back into the hospital.
The rash and itchiness cleared up. Yet, now my body is full discolored with dark blotches where the rash was (back, arms, chest, legs, stomach, neck and face).
I'm totally humiliated when I'm in public because the discoloration is clearly visible and it looks as if I have a disease.
In addition to that, I can't even wear most of my wardrobe anymore because I hate to expose my skin.
Looking at my before pics is a sad reminder that I've been scared for the rest of my life.
I've consulted an attorney who quickly told me that I had no legal recourse.

I got the Mirena put in in October 2007. I had just lost all my post baby weight and was feeling GREAT. then I immediately gained 20 lbs. I tried EVERYTHING to lose it. I went to extremes...power walking 5 miles a day, going to fitness classes, lifting weights, bicycling up hills, playing soccer with my kids. AND eating very healthy, small portions, minimal fats, no starches, or sugars, no eating out ever. NOT ONE POUND moved. What is so weird is the way the weight came on. It is all concentrated in this perfect little round bump on my belly making me look about 4 months preg. I can tell there is a lot of water there and I retain water terribly. I bloat all over so badly by the end of the day, I have to unzip my pants (even though I barely eat). I went to my doc thinking something is wrong and she assured me it wasn't my IUD but my age!!! After reading these and other posts, I was amazed to see SO many other symptoms I have been having since Oct. of 2007 that I Never attributed to the Mirena!!! My breasts hurt, my energy levels are up and down. I have had a terrible time emotionally, handfuls of hair falling out, NO SEX DRIVE, (don't have acne), irritable, depressed, impatient, headaches, complete space cadet, inability to make decisions, etc. All this since the Mirena was put in. I TOO want my body back and my SELF back!! I have an appointment in TWO Weeks from today to get it out and I cant wait!!! This can NOT be healthy!! I will report back to you and let you know what happens.
L.

Hi All - I have been off prednisone for one week and I am not doing as well as I thought I would be at this stage. My symptoms are not flaring, which is a very good thing but I am so tired and feeling very depressed and low energy. I thought I'd feel great once I was off the evil prednisone but so far I am feeling almost as bad as when I was on it. My moon face has not started to go away, which sucks, but I guess I have to be patient. I am so tired of this situation as it feels never ending. Part of the problem is I have continued to work throughout my ordeal, and it's been very hard at times to carry on like a normal person who is not sick. I have been sick since last November (with an autoimmune disorder) and I had really hoped by this time that I'd be on my way to being better :( Prednisone saved my life but the side effects are horrendous, as are the after affects of it. Good luck to all who are taking it. I share your pain and frustration.

I've been on Topamax for a few months now........this is the second time. The first time was in 2002-2004. I was up to 400mg for migraines & depression. It was supposed to do double duty. Well, I was stupid, to put it briefly. I couldn't remember anything. I would stop mid sentence because I couldn't think of the word I wanted to use. I lost a lot of weight, too much. I had needed to lose a little....baby weight. But I looked anorexic. So out to buy a new wardrobe. $$$ I lost a ton of hair!!!! So off it I went. The weight came back very fast....too fast I think. My friend says the same thing of her experience. THIS time I'm on 250mg.....no more than that, as per me. I was stupid for a little while, but it seems to have gone away for the most part. My hair is still falling out, so not much longer on this one for me. The reason I went back on it was for the weight loss ( and it does help the migraines). I was on some migraine meds that made me gain 40lbs over a 2 yr period(Abilify,Cymbalta). NOTHING could get off the weight. Not exercise, not diet. I've lost 21 so far, but my progress has slowed because of Wellbutrin...it makes me crave sweets. And my willpower is nil. lol So off the Wellbutrin I go. I also learned my nastiness could be from Topamax. I snap at the kids. Who knows which drug it's from! I also take Singulair. That's a story in itself. That one's gonna go too.

I had my IUD inserted at my 6 week post pregnancy check up with 13 lbs of pregnancy weight to lose. Since then I have gained 25lbs! I have never weighed this much in my life! 4 months ago I began watching what I eat and exercising which is something I've never had to do before :(
I've gained 4 more lbs since then. I feel pregnant and I look pregnant! My breasts are always swollen and I swear I could still fit in my maternity clothes if I tried but instead I just bought a new wardrobe in 2 sizes bigger.
This really stinks!

I spent the weekend reading about the development of Singulair. The early studies recognized that the first phase of the acute asthma response bronco-constriction was probably not caused by leukotrienes. They identified histamines and prostaglandins as the probable sources. I don't think that changed because the Singulair literature states that it should not be considered as a treatment for that. Leukotrienes were a source of inflammation caused by eosinophils and mast cells present in greater numbers (than normal) in airway tissue. So, it was beneficial to find a way to decrease that.

The cysLT1 receptor was identified as source of the signals that tell the cells to produce leukotriene. The receptor, a gene, consist of 337 (they think) amino acids. They modified a compound that would bind to that receptor thus blocking the cells ability to produce leukotrienes. This compound is very specific. It was formulated to bind to the "model" receptor. This compound will not even bind to cysLT receptor sub-types. (That is the good thing.) There is an enormous amount of research that discusses the genetic variability of the chemical reactions that occur in the leukotriene (calling it this for simplicity) pathway. We are also seeing that a number of researchers would like to use gene profiles to predict whether patients will respond favorably to different asthma/allergy drugs. ALL PATIENTS HAVE A RIGHT TO KNOW IF IT IS INHERENT THAT SOME PEOPLE WILL NOT RESPOND TO SINGULAIR OR RESPOND ADVERSELY.

There are many studies from the 1998 era that conclude that montelukast is not effective for everyone. Those researchers stated that it can be predicted that those people who are going to respond favorably will do that within the first 14 days or so. That conclusion would be consistent with a genetic component for efficacy and safety of Singulair. Those doctors concluded that those who did not respond within that time frame should not take Singulair for fear of harming them. That makes good sense.

The Italian researchers wanted to know if there was more going on than blocking leukotrienes in the action of montelukast. They set up a "test tube" study regarding montelukast, the cysLT1 receptor, and some t-cells that they selected. Why? Researchers always have something on their minds. They observed the death of these particular t-cells.

Montelukast is a quinoline. We basically know of quinilines and quinolones as compounds that were invented as broad spectrum antibiotics. They work because they interference with bacterial DNA so they cannot replicate themselves. Montelukast is a quinoline modified to bind with the cysLT1 receptor (a gene) and prevent that gene from activating. That's consistent with what a quinoline/quinolone does.

So what does montelukast do in blood plasma if it does not bind to the receptor because of genetic mis-match? (If montelukast does bind, then a chemical reaction has occurred and the liver will break down the by-products. Montelukast metabolized in 10-12 hours.) What happens if it doesn't bind? How long before it breaks down? Does it produce toxic by-products?

I want to know what happens to lymphocytes such as t-cells just because montelukast is a quinoline. Maybe nothing but what's up with the Italians researchers? I want to know if montelukast has the capability to interfere with lymphocytes who can clone themselves. That could be a good thing under circumstances when these lymphocytes are causing inflammation. But it could be a bad thing in the case of normal individuals with no problems.

I want to know if the bad side effects are due to the fact that the body has to break down and metabolize a quinoline that did not bind to the receptor for which it was created. The side effects of Singulair are strangely similar to what is observed in the quinolones such as levaquin. I have not as yet been able to compare montelukast as a quinoline to levaquin as a quinolone. I am hoping to find something on these categories. There may be no reason to worry that they cause similar damage. But frankly, I think that there is. There is some terrible chit happening to some people. The scariest is the neurological damage.

All of these questions would be in the everybody pharma knows to ask category. I don't know where the answers are. I haven't found them as of yet. Maybe there are no answers. We have to remember that Singulair and Vioxx were released in the same year. They have continued to be drugs under the current executive management of Merck. If the Vioxx marketing promoters had their ghost writers, why not the Singulair marketing promoters. The genetic component appears to be widely accepted but we haven't heard one thing about even that.

I think that it is sad that maybe the marketing of Singulair as one stop shopping for asthma/allergies may have destroyed the original concept. I really think from reading the original work that they knew that they couldn't engineer a drug for one size fits all. Everybody gets harmed when information is withheld.

Shame on the allergist who yelled at the mother who wanted to discuss issues. Does he know exactly who is allergic to Singulair and who isn't? Get him a dunce hat. Just because Singulair is marketed for allergies does not mean that you cannot be allergic to it. See the power of Madison Avenue? The ad agencies focus group these drugs to death. The ad agencies cleverly craft the product information. A good piece of legislation would be to prohibit consumer drugs ads.

I have been on Synthroid for about a year. I had high blood pressure and the doctor did a number of tests and found a thyroid deficiency. I started with 75 mcg and was moved up to 100 mcg.

I have gained weight in the last year - at least 15-20 lbs. It is all in the stomach. I look like I'm pregnant. It is very hard to get rid of! I am exercising my tail off, and giving up snacks, sweets, etc, and it's not going away.

I also never had problems sleeping but I do now. I'm glad I found this discussion group, because I see many others have had weight gain problems.

Thank you to all of those who have posted to this website. After two years on Yasmin, I kept attributing heart fluttering (started six months ago), horrible mood swings (past three months), weight gain (noticed three months ago), and of course, horrible symptoms of PMS (three months), not to mention the anxiety attacks. Of course, like everyone else, I didn't put it all together until today.

I started looking back to see when all these "things" started happening, and realized I was not taking any other medication besides Yasmin. Heart - the doctor said the EKG didn't show anything, but recommended a stress test, though the sudden "smothering" feelings kept on, anxiety attacks began (nothing changed in my life to bring on any anxiety, and in fact, my life has never been better professionally or personally), severe headaches on the third week, and then a noticeable weight gain (at least to me, as I work out all the time and eat healthy and could not figure out what it was). Breast size increased some, not enough to go up a size, but enough to notice my bra fitting tighter and not because of any weight lifting.

I am about to call my doctor and tell his nurse and get off these pills. I am miserable and so moody and angry all the time, for no reason. I felt like I lost my old self the past few months. Sex drive is diminished since being on Yasmin.

Does anyone know how quickly the weight comes off after stopping these pills or hormones? I have always been thin and these pills have almost forced me to invest in a new wardrobe.

Thank goodness I am not going crazy.

Even though my thyroid levels come out normal I am still very tired and no energy. I feel my metabolism is low but test results are all in the normal range. I take 112 mcg every day.