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Here are side effects posted by other members, that mention worry.
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150 Side Effects posted for worry

November 19th
2009
7:37 PM

I have had Mirena in for almost two years. I have gained about 20+ pounds, my usually high sex drive has disappeared, I have awful lower back pains that shoot down into my leg, I have migraines so severe they send me to bed. I thought this would be a worry-free choice of birth control. I am disturbed to know that so many other women are experiencing the same symptoms. I have not yet had it removed, but I am soon. Thank you to everyone that posted and helped me to understand my symptoms.

-- By cewig10 | Reply | Private Message me

November 11th
2009
6:56 PM

I was on YAZ for about 4 months. And like all medications, i gave it time. In the beginning i experienced a lot of nausea, fatigue, headaches, and severe diarrhea. And instead of clearing my skin, it made my skin absolutely terrible. i stuck it out in hopes that my body would change, and begin to get use to the hormone but it didn't. I have been having GI issues August, have been through a Colonoscopy, and everything came back normal. Ever since stopping this pill, my body has felt so much better overall, but the GI issues are still there which concerns me greatly. Has anyone else ever experienced this? My bowel movements have changed completely, and all of the specialist i have seen, say that the pill wouldn't do this. I do not believe it. I believe that the pill has messed up my GI tract so much, that i can't have a normal bowel movement. I honestly do not recommended this pill to anyone. I am 18, and to be experiencing what i am especially going to school, is so not fun. Could YAZ have been the cause of all of this?

-- By soccergirl1234 | Reply | (4) replies | Private Message me

September 26th
2009
5:24 PM

Amazing. like you I've fallen into this trap. So healthy and in shape at 59, (more like in my 40's), working out every day, happy. Now, after 2 months on Simvastatin, 20mg every other day, my shoulders and neck muscles are so inflamed, swollen and there's more hurt in my upper body than ever in my life. For the past week, I've been having trouble even getting my clothes over my head! Also headaches have started which I've never had before. I thought it was the relatively wet summer we've had this year in Denver, and was believing the weather had brought me into full-blown arthritis. I am so disappointed in myself to have poisoned my body this way, especially after telling my trusted MD for the previous 3 years "no thanks" to a satin drug. Thank God for my chiropractor sat me down yesterday for a consultation for why I was so much in pain. When she found I'd gone on a satin, the light bulb was lit. I will never taking any satin again and will work to always be as drug free as I can be after this lesson. Thanks to those of you who give me hope that I may feel better soon and I pray for no permanent damage from this "Simvastatin".

-- By babette | Reply | (1) replies | Private Message me

September 3th
2009
2:28 PM

I have been on Yasmin for just over 2 weeks now. My hair has been falling out, my skin has dried out really bad....I keep getting gastritis type feelings. My tummy keeps feeling like it is bubbling inside. And the nausea is indescribable!!! I run to the toilet at least twice every hour but am never sick!!!! If I don't eat, I feel sick. If I eat I feel even more sick. Then if I eat again I feel fine, then when I stop eating I feel sick.

This is the 3rd pill I have been on. Microgynon 30, Loestrin 20 and now Yasmin. I was told Yasmin was the best but now I am very concerned having read all of the above comments!!!!

I keep telling myself I am going to give it the 3 month trial but I'm half tempted not to.

I would not recommend this pill. Nor would I NOT recommend this pill. I think it's just the luck of the draw. Good luck to anyone.

The pill is crap!!! But in a long term relationship its just easier... no worry about getting pregnant. lol

-- By a_lou | Reply | (1) replies | Private Message me

September 2th
2009
5:26 AM

I got mirena July 1, 2009 and I've had the most insane mood swings that my boyfriend hates being around me. I am not a person who gets stressed out easily or who overreacts but the last couple months I've been literally insane. I don't feel as if I can even control myself. I've been thinking about getting the no hormone IUC instead. I have gained weight but never thought that it could be because of mirena. Hopefully the IUC would help
me to lose the weight I've put on. I like the worry free of no birth control pill but in the last 3 years I've never been this up and down with hormones. I would suggest, ladies think about the no hormones one, we may still have periods but none of these crazy side effects.

-- By cat7688 | Reply | Private Message me

August 25th
2009
9:42 PM

Wow - I can't believe I didn't stumble across this website when I was researching Mirena. I got mine in April 09 and have had a lot of random things going on that I never put it all together that it could be the Mirena. Today, I took TWO pregnancy tests - tender breasts, swollen vag, face breaking out, achy stomach and back, specific stomach weight gain - it HAD to be pregnancy!

My girlfriend told me she was going insane w/ the same thoughts until she started reading stories of other peoples issues. Now, I'm reading all of your stories and just shaking in disbelief...

Weight gain - check.
Sore back/lower abs - check.
Slight odor - check
Terrible PMS symptoms but NO period - check
Zero sex drive - check.
Hair loss - check.
Wild mood swings - check.

The list goes on and on, it's madness! Since day one it has felt "weird" when I go to the bathroom, I just chalked it up to me thinking too much about it being in there.

I'm 32 with one young child and would prefer not to have another. I'm calling my Dr. tomorrow to discuss my options. Thank you ladies for sharing your experiences.

-- By dzsteph | Reply | (2) replies | Private Message me

August 24th
2009
12:38 PM

This website is a joke! After I had my Mirena inserted 4 months ago I started reading on the internet about possible side effects. I was furious with myself that I hadn't Read up on this before the appointment. There were so many horrible reviews involving hair loss, weight gain, acne, and mood swings! I was so scared and actually thought about removing the Mirena that week. I then found multiple reviews on websites not owned and operated by other drug companies that are trying to scare people in order to prevent the sale and use of the Mirena and the side effects listed here were a 180 degree difference. I have not experienced any weight gain, in fact, I recently was able to shed 5 pounds from picking up running again (so it is possible to LOSE weight on the Mirena as well). I have had zero hair loss, have not had a pimple anywhere or any random hair growth. My live in boyfriend and I have discussed if we've noticed any mood swings or changes and my mood which is usually optimistic and positive has been the same since I had the Mirena inserted. My periods are much lighter and although they can last an extra day or two more than what I was used to, they are light and I have not had any cramping. I'm writing this review not because I absolutely love the Mirena, I think it's a fine form of BC but who LOVES their BC, isn't it all kind of a pain. The Mirena is by far the most convenient form of birth control and I don't worry at all about missing a day and the chance of getting pregnant. I'm writing this review because I encourage everyone to talk more with their doctors about the side effects and look around on the internet for REAL websites.

-- By katejbp | Reply | (10) replies | Private Message me

July 2th
2009
6:11 PM

hi everybody. i started using Yasmin about 3 months ago as i was told i had cysts. but since a month into taking it i am having really sharp headaches chest pains and mood swings. i am also experiencing hair loss. i am only 20 so i cant think what else could be wrong.can anybody help me out here as im getting really paranoid and getting about 4 hours sleep every night with pain and worry!!!! thanks x x x

-- By caroline20 | Reply | (1) replies | Private Message me

June 5th
2009
10:04 PM

UGH.... ladies i feel ur pain!!!!! i have had mirena in for about 6 months n i am soooooooo ready 2 get this thing out of me!!! i had a miscarriage in august n decided that i just didn't want 2 go through that again so i spoke 2 my doctor n she suggested MIRENA! i thought 5yrs without having 2 worry about getting pregnant was a win win situation n exactly wat i needed! i had insurance at the time n it payed for EVERYTHING so i said y not!!! so i got it put in n i felt great! i went 6 months without any symptoms n then WHAM!!!! ....constant headache, nausea, cramps EVERY SINGLE NIGHT N EVERY SINGLE MORNING, i cant lose weight, crying ALL the time, DEPRESSED n asking myself y im even alive, LOW LIBIDO(im 21yrs old!!! n i have no desire to have sex!!!!).... snapping at everybody (especially my bf) we almost broke up bc of it :-( thank God i found this website n let him read all the things that other ppl have been going through! it was just so horrible bc i would miss him all day n pick a fight with him as soon as he got home :-( then cry about it! he was soo confused!!! soo now im conscious of my moods n i try my best 2 control them... i have been trying to wait it out, hoping that my symptoms will go away but they have not gone away yet n i talked it over with my boyfriend n i decided 2 get it taken out bc i just want 2 feel like myself again... i miss ME! so i will keep u guys updated... im going 2 call planned parenthood on Monday n see if they can remove it, if not, then refer me 2 someone who will do it for little or no cost bc i no longer have insurance :-/

-- By felicial1356 | Reply | Private Message me

June 3th
2009
2:02 AM

My 4 year old Son has had diarrhea from about the last 4 weeks... we have started some tests for Celiac disease but today it only occurred to me today that he has been on Singulair for about that time frame... after all the worry and reading these other storied Im even more convinced that it maybe the Singulair..
Im just hoping that someone might read this sometime today or the next couple of days to tell me if when they come off the singulair how long did it take for the diarrhea to pass. My son had is last tablet 2 nights ago ( so he has only been off it so far for one night. But he still has the diarrhea.. should it have started to come out of his system already.

-- By cinderella92 | Reply | (7) replies | Private Message me

May 23th
2009
9:11 AM

I, too, am trying to get off of Lisinopril. I am 49, and 10 lbs over my ideal weight. Went on the drug in December 2008, 2.5 mg a day. Since then, I have been depressed, tired, had a dry cough, sometimes a pounding heart and most recently, I am now losing my hair! And, yes, my bp is normal while on the Lisinopril. I have to say, that while I knew it was making me feel lousy, the hair loss was the last straw of side effects. I went on it at a time of high stress in my life and for now, life is calmer and my bp ranges between 135/80 and 145/90 when I am off it. Thinking of some natural, healthy approaches to lower my bp. Perhaps lose that 10 pounds and get more exercise. It is the worry of a high bp that makes the lisinopril hard to give up. The side effects though tell me it is bad for my body. I appreciate this website and reading about the experiences others are having while on this drug. I am hoping my hair will come back in if I stay off of it. Has anyone else had their hair grow back?

-- By joanharper2 | Reply | (3) replies | Private Message me

May 14th
2009
4:19 PM

33 year old, 125lb female with cholesterol of 234. I was put on Simvastatin 40mg, which I took fot 3 night only. All hell broke loose, insomnia, hands are numb, severe joint/back pain, extreme weakness... The thing is, I took it for 3 nights & realized it wasn't for me. I've been off of it for 3 weeks, but the symptoms still persist, rendering me pretty much dead.... I was told by a few that putting me on 40 mg to start off probably did the job... Three week of living hell & my primary physician don't have answers for me!

-- By tripster41 | Reply | (2) replies | Private Message me

March 27th
2009
1:18 PM

Well I just had mine removed today after having it about 2 to 3 weeks. The pain was nothing like what I experienced having it put in- that was completely unbearable and the worst pain I have ever experienced. I did take 4 advil this morning and another 4 before the procedure so that might have helped. I did let out a quitck yelp of pain but this time the procedure was so quick so don't worry about the pain to get it taken out. I already feel so much better having it out. My doctor indicated that one of the reasons I may have experienced so much pain is that my uterus is odd shaped. I am probably going back to NuvaRing which I really don't like but always did have trouble remembering to take the pill and didn't like the shot when I had that years ago so it will be the best choice of them all. Good Luck to those ladies on it. I hope it works out for you.

-- By floridagirl23 | Reply | Private Message me

February 19th
2009
10:45 AM

I am scared to death after reading what everyone is going through. I was put on Levaquin for 10 days and got to day 9. My joints ached so bad I thought I had arthritis, and even had my Dr. do blood tests for it (I had no idea it was the Levaquin). I am only 35 years old and never worried about arthritis before this. Also, within 5 days I started developing hives all over. Again, I was stupid and didn't realize until day 9 that the hives were because of this med. I told my Dr. and he told me to stop taking it which of course I did. I assumed the hives would go away after the med was out of my system. But a week later the hives were unbearable. I was put on prednisone (another issue altogether) and that helped the itching, but now every time I try to go off or back off the prednisone the hives come back- and they are terrible! Now my Dr. thinks the hives were from something else because there is no way that the Levaquin is still in my body. But after reading what other people are going through on this med, I am convinced this stuff is as everyone says- POISON!! I am so worried about the joint and hip pain that was so bad I couldn't stand for long without excruciating pain in my right hip. It felt like I had a one hundred pound weight just sitting on it. And my hands were the worst. I have a newborn and could barely pick him up without worry that I'd drop him. I don't know what to do.. Is there anything to do?? I'm still on the prednisone, and have been for a month. I need to get off of it but every time I do I itch so bad with the hives that I cannot function. Also because of the prednisone I noticed last night that I am getting "moon face" my face is swelling up and there are a million side effects from that drug too. How long does this last? Has anyone else fought the hives that come with this? Please help me, I am so scared!

-- By jennturner6 | Reply | (4) replies | Private Message me

January 30th
2009
12:34 AM

I had mirena inserted in 02/06. Initially i had bad migraines with blurred vision, it happened almost every month...I didn't mensurate for a few month although i have my period regularly and a pantyliner is enough for these days. my worry is recently i been having sore lips, they are dry on the outer and swollen in the inner part. Had them in oct and went away on its own and now its back....I am not sure if its mirena.I am also feeling nausea and tired... And i have no interest in sex anymore....Anyone feeling the same...

-- By nikki795 | Reply | (3) replies | Private Message me

January 21th
2009
5:03 AM

I stopped taking Yasmin about a week and a half ago. I assumed it was the cause of two anxiety attacks I had, constant lump/tightness, weird tingling feelings in my throat and chest and overall body aches and ill-feeling. I haven't felt anything severe since stopping except for a dizzy spell when my period came. I'm wondering if anyone has any idea as to how long these side effects could go away. Off and on, I still get a tightness/heaviness in my chest, and although I don't get a lump in my throat anymore, it's like a numbness and constriction in different places in my neck, and sometimes a clogged up feeling in my ears. A friend told me it takes three months for the pill to leave your system, and I have a Doctor appointment this Friday, but I'm just hoping to hear any advice/suggestions. I had an EKG, cat scan and chest x-ray and everything looks fine in my body. It's just really scary and hard to shake the worry that something worse may be wrong with me. Reassurance would be much appreciated!

-- By jennyn | Reply | Private Message me

January 20th
2009
10:03 AM

Hi-I am a 59 year old female have been taking 20mg Simvastatin for 3 months for a cholesterol level of 238 and have noticed significant symptoms that cannot be from any other origin than this medication-dry skin, change of hair texture, psoriasis and bulging in thumb joints, stomach flu, shoulder pain and tingling in hands, vision problems. I am a healthy flight attendant except for all these things that have happened in the last 3 MONTHS!!! I am seeing my doctor tomorrow to discuss a change. I want to take a natural medication to lower my cholesterol.

-- By 1dmm | Reply | (1) replies | Private Message me

January 11th
2009
5:35 PM

The only thing I liked about NuvaRing was the fact that it never bothered me while it was inside. I even had sex, and all though it would feel weird at first (while my man went deep) i was still able to orgasm. However, after just 2 weeks my boyfriend and I started noticing a lot of changes. I had it for less than 2 weeks and decided to go back to the condom instead!! Now it's been a little more than a week after i took the ring out and I am heavily spotting. It started like a normal brownish discharged for about a day, but by the following day it was a bloody mess. I have the cramps just like if I had my period, but i don't. in fact i won't until 10 more days. I am a little scared because on NR website, they listed some serious symptoms that people should see a Doctor, and "spotting for more than a few days or in every menstrual cycle" is listed there So i am a little worry. It's been 3 days of spotting, I'll give it a week.

-- By ladyblue187 | Reply | Private Message me

December 18th
2008
10:59 AM

I have been on Budeprion for about 5 weeks. I was prescribed it to help me quit smoking. The first 2 weeks I was smoking the same amount. About 3 weeks into it I started smoking less. Then all of a sudden, I just quit. Today has been 3 weeks without cigerarettes and I feel great.
However....I have been dealing with major nausea almost every day of my life for the past 5 weeks. And I only take one pill in the morning. For whatever reason, late in the afternoon til the evening the nausea hits. Some days are worse than others. Most days it causes me to have dry heaving. I have never thrown up, but I feel like at any minute I could. Eating doesn't help. But I am not going to stop taking it because of it. I seriously feel the positives of this drug out way the negatives. I just think of the nausea as a reminder of how smoking has messed up my life. My only worry is what will happen once I go off the drug. I am praying that my will power to not smoke will keep me off cigarettes.

-- By gmusuzy | Reply | Private Message me

November 25th
2008
3:04 AM

Because of a couple tragedies that ocurred in my life, I was unable to sleep. Ambien was prescribed and with it, I woke up completely rested! BUT there were several dangerous events to share with you.

I drove several times & have no recollection! If it weren't for receipts, checks, etc. I wouldn't know anything about it! I'm a married woman and I took a male acquaintance to a liquor store 1/2 hour away once!
I drove to a city an hour from my home at least once!

Additionally, I've had phone conversations, conducted business meetings, taught a religion class...ALL with no knowledge or memory of these acts.

Yes, I would find dirty dishes in the sink in the morning too! I ate so much food! I didn't gain weight though...probably because the Ambien also removed ALL inhibitions in my life. My husband selfishly took complete advantage of this...if you know what I mean. This was not right! I'm still angry about this. It wasn't until he realized that I was driving in my sleep that he encouraged me not to take the Ambien anymore...I haven't taken it for two years. I do miss it because it really left me rested. Now I only take over-the-counter products and they leave me groggy.

-- By justcallmebetty | Reply | (2) replies | Private Message me

November 13th
2008
12:29 PM

I had the Mirena put in about 4 years ago , and luckily enough I haven't had that many problems . I started early menopause at 41 and it was recommended that i use the Mirena coil cause it replaces some hormones that I lose during the menopause . Also my periods has stopped and haven't had one for nearly 4 years .
The one thing I'm a little concerned about is that i've got a strong feeling that i'm getting my periods but nothing happening. Would there be any chance i could be pregnant , even though my friend who's a nurse says it's unlikely but the worry is there . I'm afraid to do a test in case it comes out positive !!! , I'm now nearly 46 ... any similar experience would be greatly appreciated .

-- By concerned999 | Reply | Private Message me

November 8th
2008
5:56 PM

Hi, I had my coil removed on Tuesday. I was bleeding after exercise and after sex (although I haven't really felt like sex very often since having it fitted). I went to my GP who checked the coil - said it was fine and suggested a scan. I then had my scan and was told the coil was in the wrong place and I needed to have it removed. I have had it removed and am now on day 4 and passing dry clots and flooding alternately. I have to say in the 10 months I have had the coil I have gained 2 stone. I had a baby in November 07 and was only 2 stone over my start weight - i had put on 4 during the pregnancy and since having the coil I had gained that back and more!!!! I look like I am still pregnant and initially after having the baby i didn't look like that. I am so moody and forgetful that I had put it down to post natal depression and am now on anti depressants. My skin hasn't been a problem which had been my main worry as I got terrible acne with the mini pill which is progesterone based. My hair is incredibly thick and I put hair loss down to post baby hormones. My bleeds were light and the spotting wasn't heavy but just a nasty surprise when it happened. I am so pleased now that it was in the wrong place and that i have had it taken out. I just hope I return to normal now. Birth control is my major worry as I can't take the pill so maybe condoms it is but at the moment I have to await the reawakening of my sec drive anyway.
Hope that helps - I would seriously not recommend it.

-- By bevmumof3 | Reply | Private Message me

November 3th
2008
1:06 PM

I am a new poster & am excited to be a part of this discussion !! I feel to close to this discussion because I have been experiencing the same issues.
I too have been having major chest pain issues for almost 2 months now. I started Yasmin (much to my dismay!) about 6 months ago. I haven't taken any b.c. since I was about 19, I am now 30, I started because my periods were absolutely unbearable anymore, intense cramping, heavy flow & in incapable of work/activity for the first 2 days. My doctor always pushed b.c. on me for the pain relief. Finally I agreed. I started in February, 2008.
Almost 2 months ago (7 months into Yasmin) I was getting a bit of chest pain along the ribs/inside of the side of the breast, mainly the right & sometimes on the left. I wasn't too worried as I am a healthy eating, yoga/work-out doing, average weight, no health issues what-so-ever except for my intense period kinda gal. About a month went by with increasing chest pain & I went to the hospital (up north at my moms when I was visiting, only an hour wait to get in as apposed to the 6 here back home!). My fear was heart problems. They did blood work & (I am not sure what this is called!) they hooked me up with tons of little stickies & monitored my heart. - I mentioned to the doctor I was taking b.c. & he said it wasn't an issue, they usually pose blood clot risk....not my issue here.
They said everything was normal & because of the sensitivity of the chest pain (it is sore to the touch!) he said it was costochondiritis, the inflammation of the chest wall. So I thought that was it, I would just take the Advil the suggested 3 times a day for inflammation & it would go away. I did this for 2 weeks & nothing changed.
I was getting some shooting pains in my chest & went back to my doctor, explained my visit up north & what they concluded it was. She said that the costochondiritis has made me sensitive to acidic foods, prescribed me with previcid for a week. That didn't make any difference at all.
Here I am another month later & my chest pain feels worse, my chest still feels tender to the touch, I am short of breath going up the stairs, heart racing/palpitations, gas (burping & passing gas), some upper back ache, I am feeling helpless & beat down !!
By now I'm sure there is a bit of anxiety mixed in there, I have been so sad, scared & worried!
I went back to my doctor & she sent me for an upper G.I. to rule out acid reflux & it came back normal. I also did some blood work again (which have since came back normal) & am waiting for the results. She said she doesn't think it's costochondiritis now. I am scheduled for an abdominal ultrasound & with a cardiologist (I go tomorrow) for an EKG for my heart.
Last night my hubby & I were talking, my co-worker was really upset to hear I've still been taking the pill, she thinks it's poison. I told my guy that & we got out the information booklet from my Yasmin & there were ALL of my symptoms, there was a list of 12 & I had 8 of them !!! No vision or numbness problems but all of the chest pain/breathing issues.
I took my last pill 2 days ago (it was my last before my period) & I have no plans to start again. I am going to follow through with the scheduled appt.'s just in case but my hubby & I have our money on the pill being the cause for all of this.
1 thing that gets me is when I went to my doctors with this issue in the beginning, not once did she bring up the pill or say to stop the pill. In the booklet under all of the symptoms I've been having it says to immediately stop taking the pill. ;(
After taking my last pill I felt a bit better (it's only been a week/my menstruating week), the sharp pain on the inside/side of my breast/chest has not been as sensitive to the touch. I still have had palpitations (minor, not lasting long - to lasting up to 4 hours until I just go sleep to try to get rid of it) & sparse shooting/dull/aching pain in my chest/armpit.
YASMIN SHOULD BE BANNED !!

-- By billie12345 | Reply | (2) replies | Private Message me

October 31th
2008
2:54 PM

Thank goodness for this site!! i couldn't figure out why, after walking nearly 4 miles a day, eating right, etc., the reason why i kept gaining weight. i got on the scale Wednesday and nearly had a nervous breakdown. i can't think straight because i'm buying size 18 pants now and started in a VERY small size 14, sometimes 12.
My question is, does anyone have any information as to how long it will take to lost the weight? i'm so distraight. i look like a fat, bloated pig. :-( i've put on over 20 pounds. i started out trying to lose 10 pounds and gained 21 since i had mirena.
Please help me!!

-- By fatmirenachick | Reply | (4) replies | Private Message me

October 22th
2008
4:57 PM

I am re-posting this from June. I believe that we have many reasons to suspect that Singulair does indeed penetrate the blood brain barrier. I personally believe that under certain unusual conditions that Singulair can cause neurological damage. I tried before to put together a scenario of brain biochemistry that could explain how this can happen. Of course, I am just hypothesizing and all of my ideas will not prove to be totally correct. From the number of postings here regarding neurological symptoms, I believe that there is an answer out there somewhere. Why the FDA is not searching for this answer is a complete mystery to me.

I believe that it is possible that Singulair causes the same biochemical response in the brain that is cited in this study -- thus causing neurological damage.

"Thus, elevated NO production leading to mitochondrial dysfunction, glutamate release, and excitotoxicity may contribute to neuronal death in neurological diseases."

IS SINGULAIR CAUSING THE DEATH OF NERVE CELLS IN SOME PATIENTS? DOES THIS HAPPEN - ALTHOUGH INFREQUENTLY- BECAUSE OF GENETIC OR BIOCHEMICAL FACTORS OR BOTH?

June 12th
2008
2:56 AM
I have stated many times that I am not an expert. I just post what I find. This has been a mind boggling journey for me. This is way over my head but I struggle to read and understand. Finding answers to why children are suffering from neuro-psychiatric side effects is worth the effort.

I have made the following observations.

1. Some quinolines are known to be able to cross the blood brain barrier.
2. Molecules that ionize are known to be more likely to be able to cross cell membranes. So if montelukast ionizes as a result of change in blood pH to sufficient acid conditions, then it could be possible that it does in fact cross the blood brain barrier.
3. We know that there are cysLT1 receptors in the brain.
4. We know that researchers believe that montelukast may bind at the arginine of the cysLT1 receptor.
5. We know that arginine contains four nitrogens. And montelukast contains one.
6. We don't know what happens to those nitrogens. Are those nitrogens converted to nitric oxide?
7. We do know what macrophages create nitric oxide as I posted.
8. We do know that if something cause excessive nitric oxide to build in the brain that there would be damage to the neurons.

Some people may remember when I got stuck at the astrocytes, the cysLT1 receptors and glutamate. I keep looking for research reports that may shed more light on this.

Titre du document / Document title
Nitric oxide causes glutamate release from brain synaptosomes
Auteur(s) / Author(s)
MCNAUGHT K. S. P. (1) ; BROWN G. C. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Biochemistry, University of Cambridge, Cambridge, ROYAUME-UNI
Résumé / Abstract
We determined the ability of pathological levels of nitric oxide (NO) to cause glutamate release from isolated rat brain nerve terminals using a fluorometric assay. It was found that NO (0.7 and 2 μM) produced (4 and 10 nmol/mg of synaptosomal protein) Ca2+-independent glutamate release from synaptosomes (after 1 min of exposure). Spermine/NO complex (spermine NONOate; a slow NO donor) and potassium cyanide (an inhibitor of cytochrome oxidase) also caused Ca2+-independent glutamate release. Preincubation of synaptosomes with 5 μM 1H- oxadiazole quinoxalin-1-one (an inhibitor of soluble guanylyl cyclase) had no effect on NO-induced Ca2+-independent glutamate release. Ca2+-independent glutamate release produced by NO was greater in a low-oxygen medium. NO, spermine NONOate, and potassium cyanide inhibited synaptosomal respiration with a similar order of potency with respect to their ability to cause glutamate release. Because NO has been shown previously to inhibit reversibly cytochrome oxidase in competition with oxygen, our findings in this study suggest that NO (and cyanide) causes glutamate release following inhibition of mitochondrial respiration at the level of cytochrome oxidase. Thus, elevated NO production leading to mitochondrial dysfunction, glutamate release, and excitotoxicty may contribute to neuronal death in neurological diseases.
Revue / Journal Title
Journal of neurochemistry ISSN 0022-3042 CODEN JONRA9
Source / Source
1998, vol. 70, no4, pp. 1541-1546 (29 ref.)

INIST-CNRS, Cote INIST : 4037, 35400007527188.0230

-- By concernedcitizen | Reply | (6) replies | Private Message me


 

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