I have been on Zoloft for about 2.5 months. This is due to increased anxiety/panic attacks that I would have. The first month was torture. Three weeks in I thought I needed a white coat with silver buckles on the back. After the 5th week things finally started to level out. I sleep 110% better. I do have the diarrhea issues - as long as 3 weeks at one time. I've had about a 10-15lb weigh LOSS. Overall I'm very pleased with how it's worked out for me