22.5 mg every three months for prostate cancer. hot fllashs, sweats, body took on female appearance, hair loss on upper torso, swollen breasts, sensitive testicles, shrunken penis, Low back ache, weak legs, loss of equilibrium. Second opinion urologist took me off lupron, said it wasnt necessary. No problems with prostate at any time. Reaction disappeared except for low back ache, weak legs, equilibrium, shrunken penis which I have had 4 years and may be permanent.