My fifteen-year-old daughter was taking Doxycycline 100MG capsules twice a day for about 6-7 months for moderate acne when she started to have a painful constant burning sensation in her upper stomach area. She stopped taking Doxycycline and within a couple of days, the pain was completely gone. Three months later she began to take it again, within four short days the same symptom returned. Once again, she stopped taking the capsules and the pain was gone in only one day. We are absolutely certain that Doxycycline was irritating her stomach and is no way a coincidence.