I have been off Advair for 7 months now. After quitting, I first got my voice back -- it had been cracking and disappearing by the end of the day. Then the swelling in my ankles went down. I was able to stick to a diet, and now I realize I looked like I was pregnant, my stomach was so big. I've lost 15 pounds on a realistically low-carb, low-gluten diet, fairly easily. I'm running again, finally with no muscle pain, and more lung capacity than I had on Advair. I've had a cold virus twice, and didn't become asthmatic, even though EVERY single cold had in the past. I was up to 500/50 when I decided to quit, and my doctor had told me I would likely have to stay on that dosage forever. (I'd had to supplement with Albuterol when I tried to exercise, and frequently had nighttime wheezes.) She was wrong. Advair is BAD NEWS. If you decide to quit, taper off gradually, over a few weeks. I went through a bad spell of painful headaches in the week I tapered.