I took Yasmin for about a year and had no problems. I just started re-taking them again and have had nausea and tiredness. They also make me more anxious. I took Ortho Tri Cyclen Lo which is supposed to help your skin and got massive acne like I've never had before in my life - I looked like a 12 year old boy! I will NEVER take that stuff again. If Yasmin doesn't work out I'm not sure what I'll do - I know I'll never take Ortho products again though!