I have been reading about this now for three hours, and it has made me feel both better and worse. I have been on antidepressants for over 10 years; I think I have been on Effexor for around 4 or 5. It has all but banished my panic attacks; I haven't had one in months now, and those that I have had over the past few years have been endurable to say the least. What worries me is the changes in my personality that have taken place over the past decade. I have been thinking that what I have been experiencing is my depression getting worse and that I have been spiraling down into severe mental illness. It's frightening to say out loud that you think you are going crazy, and so I have managed to keep a tenuous hold on reality and ever onward I go. I mentioned my symptoms to my doctor almost 2 years ago, and her response was to increase my dosage to 112.5 a day. This only served to confirm my belief that my mental health was indeed declining. After reading these posts I want to weep with joy that I am not crazy, it is this magic pill that I take every day. I too have avoided going off Effexor because of the side effects; it seems that it would be easier to withdraw from a serious heroin jones with less suffering. My side effects while being on the medication have been: loss of interest in everything in life that ever interested me, weight gain with loss of appetite (go figure), loss of sex drive and almost an aversion to sex or intimacy, fatigue, confusion, and an emotional withdrawal from those around me. The few times I have tried to go off Effexor (or missed a few days due to forgetfulness or lack of interest in going to the pharmacy to pick them up), my symptoms have been: that weird feeling of your brain having to catch up to your eyes, that feeling of being shocked or zapped, a descent into depression equaling the speed of an Olympic bobsled run, a feeling of hopelessness, headache, cotton mouth, diarrhea, mood swings so severe and radical that I frighten myself, irritability to the point of wanting to chew off my own fingers, tears over everything and anything, and restlessness. Reading over this, I'm thinking that being depressed was not so bad after all. It's kind of sick to wish for simple depression; it reinforces my belief that this medication is bad. I see that in another post someone is asking if there is any rumble of a class-action lawsuit; I would also be interested in this information. Thank you for sharing what this medication has done to all of you, and I hope that my post helps someone else with similar experiences.