I have been on prednison since l980. I was told I had steroid dependent asthma. I briefly had moon face. I was very organized. I even typed my honey do list for my spouse. I was "driven" to get tasks done. I had difficulty sleeping, muscle cramps, frequent night time urination. easily bruised on my forearms when I bumped into things, lots of 3 corner skin tears and recently had a bone density test and now I have to take Boniva. I did not gain weight. Over the last two years I went from 140 to 120. I did experience two very serious illnesses (Throtoxic with Thyroid Storm and a spinal tumor and surgery.) I finally weaned off about 3 weeks ago. I went from 10 to 5 to 2.5 to 1.25 then 1.25 every other day - very slowly. No asthma symptoms yet. At this time I fatigue very easily. I have lost subcutaneous fat in my forearms, feet and face. I still have some muscle cramps in my feet and somethings deep in legs. I am sleeping much better. I am wondering if the loss of fat has anything to do with the long term use of prednisone. Has anyone experienced or heard of this connection to Prednisone?