I too have been on Advair for 6 months and gained about 20 lbs, despite working out at the gym and dieting. I have been on it for approximately two years and hoping to see the Dr. next week to supplement this drug and get off of it! Although it helps my breathing tremendously, I have terrible acne, weight gain, and wondering if it is making my hair somewhat thinner. I am on 100/50. One year ago I was on the 500 dose and experience chronic horseness along with thrush on tongue and throat. Does anyone know of an alternative to this drug for asthma? Thanks!