Terrible leg pains at night while sleeping, muscle aches, weight gain, and maybe loss of sexual drive is caused by toprol. I was prescribed Toprol for migranes. It has cut them down tremendously but the pain in my legs at night will cause me to discontinue. Today is New Years Eve and I will be calling for an appt for the Dr on Tuesday. I have many more symtoms but I don't know if I can blame them on Toprol.