I find all of these reports interesting. I have a varied background of medical problems and am on medications for thyroid, hormones, and have been taking methotrexate for a couple of years and now remicade infusions for psoriatic arthritis. I've also been on Zocor for a couple of years now. The psoriatic arthritis symptoms (and I also have been diagnosed with fibromyalgia) are quite similar to the "side effects" being attributed to Zocor. This last couple of weeks it has escalated to the point that I can barely walk or grasp anything in my hands. I'm relatively okay when I first get up in the mornings, but after an hour, my feet, ankles and legs ache like they're severely bruised and my shoulders and upper arms and hands are similarly sore. My rheumatologist is having me get some lab studies this week because he thinks the culprit is the Zocor. I'd hate to think I've been dealing with all this discomfort the last couple of years thinking is was due to the psoriatic arthritis when, in fact, it's a side effect of the Zocor. But life would be much more pleasant if I can go off the Zocor and not experience this kind of pain. At least all your comments give me positive thoughts that perhaps this discomfort will be in my past soon. Thank you all.