I think what you mean is your daughter is down to 2 pills and wen...

I think what you mean is your daughter is down to 2 pills and went back up to 3 pills? each pill is 5mg so she is now back to 15mg? I also started at high doses like that, two times. Once at 50mg and the second time at 60mg because of a complication due to a surgery. I don't know if any problems that you mentioned are specifically due to prednisone. It does affect the adrenal gland hormones, but I'm not sure it affects the sex hormones (menstruation and breast soreness). My cycle was not affected by prednisone. I do know the mood swings and anxiousness are normal with prednisone. But even though it is the nature of the drug, my particular doctor assured me that at the low level of 2 pills or 10mg a day, it shouldn't be as severe as on the high doses. In fact, we should be feeling a lot better. But of course it depends on our personalities as well. It is normal though, I feel, to have depression, fears and anxiousness just because we have been sick, and perhaps been sick for a long time. Please, with any mood problems, don't dismiss it completely as the drug's fault, especially if you are at a low dose and still feel miserable. We need support if we are sick, and need to understand and deal with our changed lives. It is very stressful to be sick. Good luck to everyone and I wish you strength and healing. Patience.