I have been on predinsone for 14 1/2 years. I have had weight gain on and off and now I am up to 270. I have chronic asthma, MS and bad allergies. I had seen a specialist years ago and they said I would never go off prednisone. I am dependent on it. Two different times in these past years I had gone down to two 1/2 mg. I was able to lose weight and I felt pretty good. I went down 85 pounds. I promised myself never to let it happen again. haha. I have 6 children and 3 grandchildren. I am 44 and have been married 23 years. My husband loves me the way I am (so he sayes) but I am very depressed and unhappy about the way I look and feel. I have moon face, I am obese, I have the lump on my back, I am taking numerous other medications for my asthma and MS. My nurologist has given me some anti depressants and I guess it helps but sometimes I just feel like asking if it is all worth the trouble. I can't take it sometimes, I just want to run off the side of the bridge. Then I think about my family and my mom who lost two sons, one to asthma when he was 17 and one who was shot when he was 21 and I know she couldn't take losing me. I recently had a dose of solumedrol in the emergency room and the next day my doctor took a CBC and dif. It came up that my wbc was 20,000. He said that was very high and I just wanted to know if anyone else has had a high white blood count after a dose of solumedrol.