i have been on advair since august o5, i have gained a lot of weight, i am in extreme pain at all times, i can hardly get out of chairs & out of bed, because of the pain im in, my hands go numb With hot tingling sensations, & have to walk with a cane now, & can barely stand for very long!!! i have c.o.p.d. & im on 250-50, the only good thing is i can breathe!!! im 45 years old, im gonna try & stop this medication, i dont know what will happen, but i guess ill find out.....................