Advair caused me to have severe joint pain in my knees and hips. It was as though i had severe arthritis. There was also a severe pressure feeling behind my knee caps I had bad headaches, acne, sharp chest pain and was seriously irritable.I realized it was the advair after i had been off of it for several weeks due to losing our health insurance all my symptoms went away and returned three days after starting the advair 250/50 again.