Just started Levaquin 250 mg for a UTI, have only taken one pill (last night) and experienced the most wicked nightmares and disorientation upon waking that I have ever had. Fell asleep at 10:30, awoke at 12:00 and was up the rest of the night with insomnia. I remember my sister in law telling me her husband experienced depression, nightmares and palpatations after being on Levaquin for a few days, and that is what I initially thought of after my head cleared a little last night. Got up, read the PDR (probably should have done that BEFORE I took the meds) and then found this site. Thinking back, I stopped taking this two years ago when I had palpations and severe anxiety. That's it for me!