I am becoming so *itchy! The mood swings are horrendous! I suffer from Crohns and have to take large doses of Prednisone. Right now I'm on 40 mg daily for 7 day, then 30 mg's for 7 days, then 20 mg's then 10 mg's! I'm still in the 30 mg's and feel like I'm going to have a freakin' heart attack because my nerves are so rattled. I am ready to cry one minute and ready to fight the next. My poor husband and son are trying to be supportive but I don't blame them for getting tired of it, I'm tired of it. Has this been the case for any of you? Also, I am up a good 5-6 times nightly to pee! And I mean, can't hold it any longer, gotta go right now kind of pee! Is this supposed to be a side effect? Does it signal something bad? Any advice from any of you would be very helpful. I haven't gained any weight from taking the meds yet but I'm fearful of it and fearful of what I've heard is called "moon faced" ???? When the information says "prolonged" - how long is considered prolonged use? A month, a year, longer? Any advice is appreciated! Angel