I've had 2 lapo surgery's and 3 yrs ago I went thru a different type of Lupron shots. A year ago my endo pain returned in full force. I started my new set of Lupron shots 2 weeks ago. My first concern was that my period lasted 10 days and That's never happened before. And now I've started having horrible migraines not to mention the mood swings and nightime hot flashes. But so far it's all worth it because my extreme endo pain is almost gone. Hopefully it will all be gone soon.