I have been on Yasmin for a few weeks now and have gotten so depressed and have also noticed weight gain and water retention. I notice these same side effects whenever I begin taking a birth control, but my doctor says I need to take them because I have something similar to endometriosis that causes uterine pain without them. I also have excruciating periods. I have taken Allese and Ortho Tri-Cycline, and another pill recently that I can't remember. Has anyone found a pill that does not make them gain weight and despair? I almost think dealing with the pain was better than this. Now every waking second is affected, not to mention broken sleep. I think I'm just going to ditch them. Any advice would be great.