I started Singular a month ago and added Advair 250 to it 2 weeks ago, and stopped using the Singular. I noticed slight weight gain with the Singular and rapid weight gain with the Advair, overall 10 lbs in a month. I've maintained the same weight for many years, and am a fitness instructor, nothing else had changed in my lifestyle. I've also noticed muscle heaviness, and muscle soreness, chest heaviness when climbing stairs, extreme nervousness, anxiety, and sore, sore throat. After 13 days I quit the Advair entirely. I will pursue more conservative methods of controlling my asthma. I'm not convinced these steroid concoctions are the way to go.