I started on advair in 2001 for about 2 months, and all was good. I started back on 250/50 in late 2005, until March 2006. I take no other meds except advair. I've noticed hardening of viens in my neck which went away when I stop my dosage. My liver has been giving me trouble as well. The doctors say it's not the drug. I've totally stopped using these meds. My symptons are subsiding. I feel they don't know enough about the long term effects of the meds. I'm african american and as we know most of these drugs have varying side effects on different ethnicities.