I started taking advair 500/50 about 6mths ago after coming down with really bad cold which later turned into pneumonia. I was on albuterol inhaler 5-6times a day for 3 mths. The advair made a big difference. I'm now on the 250/50 which is great. But I've had increasing problems with anxiety as well as muscle spasms in my hands. My doctor immediately recommended anxiety meds instead even entertaining the idea that it might be the drugs I was on. I refused to take anxiety meds and instead on her recommendation started exercising regularly and have started seeing a phychologist. I also tried Singulair briefly but developed rash on my face and had sudden cold symptoms which went away once I stopped taking it. I'm not crazy, my side effects are real and I'm convinced that the muscle spasms are due to my medication, most likely the advair. Currently I'm on rhinocort, albuterol for emergencies, and advair 250/50. I also had allergy testing done and am very allergic to everything they test for except animal dander i.e. grass and tree pollen, ragweed, mold, both kinds of dust mites. I keep taking my meds, exercising, cleaning regularly, have encased my bedding to control dust mites. I'm also taking allergy shots every week now. The thrush can be avoided if you rinse after every dose of advair. Rinsing is very important - I've had no problems with thrush at all and am now in my 7th month of taking Advair.