I HAVE COPD AND MILD ASTHMA AND HAVE BEEN ON ADVAIR 250/50 FOR ABOUT 4MONTHS I HAVE HAD THE ACNE, WEIGHT GAIN, HEADACHES, VOMITING, STOMACH CRAMPS, MOOD SWINGS, RESTLESSNESS, AND JUST FOUND OUT TODAY THAT I SHOULD HAVE ALREADY BEEN BACK TO THE DR AND WILL BE GOING TODAY FOR ITCHING AND HIVES WHICH I HAVE BEEN EXPERIENCING DAILY. IF YOU DO EXPERIENCE HIVES YOU ARE SUPPOSED TO CONTACT YOUR DOCTOR IMMEDIATELY.