I am 20 years old and have been on Advair 250/50 for 5 days. Already I am experiencing extreme fatigue, a sort of spacy, hypnotic feeling, anxiety, depression, mood swings, dry mouth, thick phlegm, constant throat clearing and it is ruining my life. I'm in a tap dance company and have not been able to perform even simple rountines. It has also placed a strain on my relationship with my boyfriend due to the mood swings, depression and increased irritability. I am harder to be around and he doesn't understand why. I am so glad I checked this site. I thought I was going crazy.