I have been taking topral xl for about two months and feel worse than before I started it. I had mitral and aortic valve replacements 4 years ago and recently started having preventricular contractions. The doctor has not been able to determine the reason this has started, but Dr put me on topral xl to stop them. It has stopped the contractions, but I have gained a lot of weight, have increased depression, fatigue, tingling toes, sore breasts, extreme bloating and constipation and overall feeling terrible. I feel that I would be better off just learning to cope with the contractions than having to deal with not wanting to do anything at all. I have always been an active person, even after the heart surgery, but now all I can do is sit. I can't get the doctor to understand that the cure is making me feel worse than the problem. Granted, preventricular contractions is no picnic, and causes a lot of anxiety, but now I don't have the energy or inclination do do anything. What good does it do to have me gain weight and be so depressed and fatigued? I really feel that I would rather have a pace maker than all of the side effects of this drug.