I gained about 10 pounds since going back on prednisone last summer and followed the South Beach Diet which seemed to work as it has kept my blood sugar undercontrol and eleminated alot of the cravings. I have just recently gone back on Zoloft for the depression and it has lessened my appetite - which is one of the side effects. However, I have found that weight training which I kept up from when I did physical therapy, has had the most benefit for keeping things under control - not to mention the good mental benefits that come from working out. Lately I've had to drag myself to the gym but it is always worth it.