i have felt terrible on synthroid it just gets worse every day and i have been on it for 6 weeks now i feel very anxious tired my skin is parched my sinus is worse i have weakness in my joints i don t sleep well i am extremely depressed and i have thought of taking my self to the hospital many times and my appetite just went away the second day on this drug i have lost too much weight and with it went strenght too i don t feel like doing anything i use to do maybe it was the surgery of removing my thyroid or the treatment i went through for the cancer maybe it was being with out a thyroid or replacement for 3 weks which is what you must do for the treatment but after the 3 weeks and i went on synthroid .137 i have felt nothing but horrible