Been on Zoloft for 7 years - from 100mg and now 200mg daily for depression and mild anxiety. I have terrible headaches when I miss two days or more (my fault, of course!). I also found that my depression and mood swings were TERRIBLE when I first tried birth control pills (as someone else mentioned). However, different BC pills will have different effects and I have now found that Lo-Ovral is a a good match for me (after my Dr increased my Zoloft daily intake by 50 mg).