I have been on advair for at least three or four years and now have been dependant on it. I have gained 55 pounds and I never had a weight problem. I started getting very stiff knees and elbows with leg cramps but shrugged it off as part of the weight gain. Occasionally i get heart palpitations and dizziness and I also have developed serious heartburn or reflux at night. I never thought all these symptoms were related until I came across this website. I am amazed that other people are going through this also.