I've been on doxycycline for two months now for adult acne. My acne got pretty severe, but has calmed down a lot due to the medication. Originally my doctor prescribed me minocycline, which is in the same family (tetracyclines), because of my hunger with the doxycycline. The minocycline gave me an incredibly bad migraine, the worst in my life. I was unstable, and dizzy. After doing research on the net and talking with the pharmacists I work with ( no, i'm not a pharmacist, i am just a tech) we agreed it was intracranial hypertension and that I needed to stop right away. Being on the doxycycline doesn't give me nearly the headache I had being on the minocycline. I found that when I take the doxycycline before bed OR if I am not upright at least at a 90 degree angle, my esophogus will begin to burn.. I usually fix that with drinking A LOT of cool water and it goes away. My doctor told me to take the doxy twice daily, but I find that taking it once daily does the trick for my acne, it just takes a little longer for it to clear up. I guess I'd rather my acne take longer to clear then to have all the side effects everyone else is having.... which I have experianced. But like I said I take it two hours before bed staying in an upright position with lot's of water at hand... and I'm completely fine.