I have been taking 20 mmg of prednisone three times a day. I'm taking it for lupus, and I have gained over 10 pounds in a week. It makes me feel wonderful, but I hate the side effects. I am gaining so much weight, my face is so fat and people continuously ask me if I'm pregnant. Also it stops me from staying asleep but not from going to sleep. However, that doesn't bother me so much.