I have not experienced any hair loss or weight gain with this drug. I take Depakote 250 milligrams 3x per day for migraine headaches. Once in the morning, and two in the evening. What I do get is an unbelievable case of indegestion. I always make it a point to eat when taking this medication. I was also wondering if anyone has had a decrease, in thier sexual desire ? Being on this drug? any comments would be greatly appreciated