I've been off and on Advair for two years. I'll take myself off of it cause I don't like what it does but then the asthma goes nuts. So far I've been on this for three days - 2 doses per day of the 250/50. Massive joint pain like I have the flu, dizzy, ear-ache, nausea, sore-throat, hoarsness, headache, lethargy. I am also on Zyrtec every day 1 pill to control post-nasal sinus drip which kicks off an asthma attack. One more note. I moved to Massachusetts 6 years ago from Alabama. I had two sinus problems a year in Bama - bronchitis type stuff and that was it. I was diagnosed with Asthma 2 years after moving to Massachusetts.