I have been on Advair 250/50 for 2 years now and it has been a MIRACLE drug for me. I have moderate/severe asthma, diagnosed at 11 and now I'm 43. I was constantly taking puffs from my albuterol inhaler and now I rarely use it. I was initially prescribed Advair 2x/day but reduced to once a day because I felt "jittery" on 2x/day. Occasionally, I get some hoarseness but it's the Kathleen Turner sexy kind of hoarseness, so I don't mind. I have never had any adverse side effects from this drug other than the jitters but that was gone once I went to 1 dose a day. I also take Singulair for asthma.