After 2+ years on Topamax for migranes (25 mg am/pm) I started to have shortness of breath. Couldn't even walk a flight of stairs, and I am distance walker in great shape. After lot's of tests Dr.'s said it couldn't be a side effect since I had been on it so long. They were WRONG!. Quit and now a week later I am about back to normal. After quiting also feel no neck/back pain. Irritability gone also. I hope my migranes don't come back. So far no problem. But the side effects are worse than the migranes. Especially the SHORTNESS OF BREATH!