I want to say first that I have been taking 50 mg. of Zolft now for about 5 years. I take it at bedtime. I hve only forgotten to take it once or twice in five years. The times I did forget however, I would have very strange images in the black space when I close my eyes. If I could get up and take it before going to sleep, in about 20-25 minutes the images would stop and I would fall peacefully to sleep. The nights that I did not take it at all I would have very strange and disturbing dreams. Even with these minor side effects, Zoloft is still one of the best things that has ever happened to me. It has made such a change in my life that I can't say enough good about it.