My Endo priscribed this to me for high BP, and I am also assuming for the left adrenal gland mass I now have. So far the side effects I've had after he raised my dosage were painful tender breasts and lack of sex drive. After complaining to him he lowered my dosage back down to 50 mg. Anyway, the problem I've encountered since being put on Spiro is irregular periods. I've had 4 within the last month and a half! My doctor tells me the periods will balance itself out after a few months - a few months?! I don't know how much longer I can handle having periods every 10 - 14 days! It's bad enough having them, but having double what I'm used to is insane! Also, Spiro has not lowered my high BP - it seems to have raised it - it's just a nightmare, but I have to take Spiro because my Endo says it takes time - ahhh well, we'll see....