I started topamax on 6/28/06, building from 25mg's to 100mg's for simple partial seizures and migraines. I'll have to say it has helped tremendously. I woke up every single day with a headache! Not anymore. All I have now, is a mild sinus headache here and there. I will say on the negative side, I have absolutely no appetite (although i stand to lose 30 lbs), numbness, tingling, memory dullness, bowel changes(yuck with bowel cramping) and my menstral flow is well off track! Has anyone else had any of these problems too? Oh and I definitely have shortness of breath. And I'm making sure to drink plenty of H2O!!!PLEASE RESPONDE!!!