I've been on Prednisone since February of this year. I started at 60mg/day and am currently weaing from 40mg/day to 20mg/day. For awhile I thought I was losing my mind. First I will say I am on this medication after being diagnosed with Sarcoidosis. The Prednisone has decreased the number and size of granulomas in my lungs making breathing a lot easier and has also gotten rid of most of the chronic pain I was in. I used to wake up barely able to drag myself out of bed. Here is a list of my side effects: increased appetite, indigestion, nervousness/restlessness, dizziness, flushing of facial and neck skin, burping, SWEATING, mental confusion - inability to think clearly, memory loss, tinnitus, irritability, mood swings, muscle cramping in legs and arms/fingers, weight gain, sodium/fluid retention, increased hair growth on facial areas. I had daily headaches for awhile but those seem to have dissapated to infrequent headaches. I'm grateful for this drug for what it's done for me but the side effects are making me feel I'm going insane.