90 days on Zocor and began having severe pain in left quads. At about 10 weeks, I noticed slightly darkened urine after exercise. I was on vacation and the pain was intense and my urine got very dark. My husband is a physician and was working out of town when I began having these problems. He did not make the connection to Zocor until he returned home and realized I had lost nearly all my muscle mass. My physician was shocked when he saw me a couple weeks later in clinic. It is 3 months later and I am still fatigued and have severe pain with exercise. I am now taking COQ10 and have stopped exercising until I feel better. My husband believed that the potential side effects of statins were far outweighed by the results. He is now very concerned about their side effects and plans to prescribe them far less often.