I was put on sulfameth for two weeks due to my acne; one pill twice a day. Yesterday, my 13th day, I woke up with sore joints. I didn't think anything about it, though I'd had a soreness in my joints for a while now, because I work out a lot. This morning though, I woke up with all my joints SCREAMING! Ankles, knees (especially), wrists, elbows, and neck. My knees, elbows, and wrists were the worst though. It eventually fades as the day progresses, but never goes completely away.