After reading the above stories, I now wonder if lisinopril is causing some of my symptoms of fatigue & strange muscle pain. I've been on 10mg/day of lisinopril for about a year. It got worse after I had anesthesia to remove a mole on my hip on June 1, 2006. I then got almost "paralysis" with extreme loss of energy and pain, especially in the left shoulder and right foot/calf/knee. I wonder if the combination of lisinopril with anesthesia caused this loss of energy. Before the surgery on 6-1-06, I could run perhaps 15-18 mph, getting a pulse of 140-147. After the surgery (I was told no heavy exercise for about 9 days afterwards), I would run at full blast, hitting a maximum of maybe 7 mph, and it was if my legs were in molasses and I could barely get my pulse up to 110! After nearly 2 months since the surgery, I can get my pulse up to 147 or so, but still have some "muscle" disturbance issues where I feel "constrained." If this does not go away soon, I'll lose another 10 pounds and stop the lisinopril!