I have been taking prednisone for six years now. I have not missed a day during that time. I had a transplant and suffered rejection. I have every side effect you can think of. Blurred vision, out of control blood sugar, pain, weakness, mood swings,thrush,acid stomach,just to name a few. I really dont even know what to do,because it seems as though my life depends on it. I think my family is getting tired of having to deal with me as I am always complaining,