I started on Lupron in January 2006 and took my last injection on June 27. I was taking Lupron for endometerosis. I had the hot flashes which were horrible, mood swings and insomnia, night sweats, and vaginal dryness. Lupron brochures states you do not want to get pregnant while on Lupron but they do not need to worry about it because sex is uncomfortable due to the vaginal dryness. It is now August and I still have not had a period. I would not recommend Lupron for anyone.