I have been on this drup for about 6 months at 50 mg twice a day. Within the last two months, the effectiveness of migraine prevention has seemed to have worn off, and I have noticed an abundance of hair loss. Has this happened to anyone else out there? I have an appointment with my physician to see what can be done about the migraine issue because I cannot go back to 4-5 migraines a week! If any of you have any experience with this type of issue and Topamax please post or let me know! Will the hair loss taper off or get worse?